S100A8 and S100A9

Number of citations of the paper that reports this interaction (PubMedID 12553726)
0

Data Source:
HPRD (two hybrid, in vitro)

		S100A8	S100A9
Description		S100 calcium binding protein A8	S100 calcium binding protein A9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Intermediate Filament Cytoskeleton Extracellular Exosome Calprotectin Complex S100A8 Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Extracellular Exosome Calprotectin Complex S100A9 Complex
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Metal Ion Binding Calcium-dependent Protein Binding Arachidonate Binding RAGE Receptor Binding
	Biological Process	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Peptide Secretion Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Chemotaxis Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Positive Regulation Of Cell Growth Neutrophil Chemotaxis Response To Lipopolysaccharide Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immune System Process Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Autophagy Apoptotic Process Chemotaxis Inflammatory Response Cell-cell Signaling Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Cell Growth Neutrophil Chemotaxis Regulation Of Toll-like Receptor Signaling Pathway Autocrine Signaling Peptidyl-cysteine S-trans-nitrosylation Defense Response To Bacterium Endothelial Cell Migration Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Regulation Of Cytoskeleton Organization Regulation Of Respiratory Burst Involved In Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Aggregation Cellular Oxidant Detoxification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins
Drugs		Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Calcium Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897) Monocyte count ( 32888494)	Asthma ( 31619474) Basophil percentage of white cells ( 32888494) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PCNA PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	13 interacting genes: CDC42 EGFR MAGEA1 MAGEA3 MAGEA6 MAPK14 NCF2 PTEN S100A8 S100B SNCA TUBA1A TUBB
Entrez ID		6279	6280
HPRD ID		00471	00472
Ensembl ID		ENSG00000143546	ENSG00000163220
Uniprot IDs		P05109	P06702
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2 7QUV 8SJB 8SJC	1IRJ 1XK4 4GGF 4XJK 5I8N 5W1F 6DS2 7QUV 7UI5 8SJB 8SJC
Enriched GO Terms of Interacting Partners?		Response To Light Stimulus Molecular Function Activator Activity PCNA-p21 Complex Enzyme Binding Response To Radiation Regulation Of Phosphorus Metabolic Process Regulation Of Growth RAGE Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Microtubule-based Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Nuclear Envelope Lumen Heparan Sulfate Binding Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Phosphate Metabolic Process Stress-induced Premature Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Forebrain Morphogenesis Cytoskeleton-dependent Intracellular Transport Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Growth Regulation Of DNA Biosynthetic Process Replicative Senescence Synapse Maturation Cellular Response To UV Mitotic G1/S Transition Checkpoint Signaling Response To L-glutamate Structural Constituent Of Cytoskeleton Synapse Organization Protein-containing Complex Protein Serine/threonine Kinase Binding Negative Regulation Of Protein Phosphorylation Heart Development Cellular Response To Light Stimulus Circadian Behavior Rhythmic Behavior Response To Amino Acid Regulation Of DNA Replication Negative Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Dentate Gyrus Development Regulation Of Cellular Component Organization Positive Regulation Of Phosphate Metabolic Process Regulation Of Synapse Organization Positive Regulation Of Excitatory Postsynaptic Potential Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cytosol Regulation Of Cellular Response To Stress Negative Regulation Of DNA Metabolic Process	Regulation Of Synapse Organization Negative Regulation Of Catabolic Process Cell Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Growth Neuron Projection Morphogenesis Learning Or Memory Forebrain Morphogenesis RAGE Receptor Binding Regulation Of Growth Dendritic Spine Morphogenesis Cellular Developmental Process Cognition Negative Regulation Of Autophagy Regulation Of Signal Transduction Histone Deacetylase Binding Cell Differentiation Regulation Of Autophagy Dentate Gyrus Development Adult Behavior Regulation Of Cellular Component Organization Enzyme Binding Positive Regulation Of Cell Growth Nucleus Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Response To Lipid Cytosol Regulation Of Cell Communication Regulation Of Signaling Cell Junction Organization Cell Migration Regulation Of Intracellular Signal Transduction Cytoskeleton-dependent Intracellular Transport Apoptotic Process Negative Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of Cell Population Proliferation Neuron Projection Organization Postsynapse Organization Tau Protein Binding Anatomical Structure Morphogenesis Programmed Cell Death Cell Death Extracellular Region Cytoplasm Response To Cytokine Negative Regulation Of Signaling Negative Regulation Of Cell Communication Multivesicular Body, Internal Vesicle Lumen
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