S100A8 and S100A9

Number of citations of the paper that reports this interaction (PMID 12553726)
5

Data Source:
HPRD (two hybrid, in vitro)

		S100A8	S100A9
Gene Name		S100 calcium binding protein A8	S100 calcium binding protein A9
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding	Signal Transducer Activity Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Antioxidant Activity Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding
	Biological Process	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Wound Healing Defense Response To Bacterium Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytokine Production Leukocyte Migration Involved In Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Response To Zinc Ion Positive Regulation Of Cell Growth Neutrophil Chemotaxis Actin Cytoskeleton Reorganization Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Defense Response To Bacterium Innate Immune Response Regulation Of Integrin Biosynthetic Process Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: APP C14orf1 CDKN1A CEACAM3 CHGB GDF9 IGSF21 KLC2 LRIF1 NCF2 PDCD11 PPIA PRMT1 RAB17 S100A9 TP53 TUBA4A UNC119	4 interactors: CDC42 EGFR NCF2 S100A8
Entrez ID		6279	6280
HPRD ID		00471	00472
Ensembl ID		ENSG00000143546	ENSG00000163220
Uniprot IDs		P05109	P06702
PDB IDs		1MR8 1XK4 4GGF	1IRJ 1XK4 4GGF
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Degranulation Immune System Process Stress-induced Premature Senescence Regulation Of Body Fluid Levels Wound Healing Regulation Of Growth Mitotic Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Response To Light Stimulus Response To Wounding Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Immune Response Negative Regulation Of Cell Growth Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Cellular Senescence Response To Hyperoxia Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Positive Regulation Of Cell Cycle Process Regulation Of Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle Phase Transition Response To Stimulus Response To Abiotic Stimulus Positive Regulation Of Programmed Cell Death Axon Cargo Transport Negative Regulation Of Growth Response To Stress Positive Regulation Of Cell Death Response To External Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Neuron Apoptotic Process Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To UV Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Clathrin-mediated Endocytosis Uncoating Of Virus Mitotic Cell Cycle Process	Innate Immune Response Immune Response Defense Response Regulation Of Apoptotic Process Regulation Of Cell Death Salivary Gland Morphogenesis Salivary Gland Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Exocrine System Development Positive Regulation Of Neuron Apoptotic Process Response To External Stimulus Single Organismal Cell-cell Adhesion Positive Regulation Of DNA Replication Positive Regulation Of Neuron Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Death Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Hair Follicle Development Hair Cycle Process Positive Regulation Of Inflammatory Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Hair Cycle Positive Regulation Of Transport Reactive Oxygen Species Metabolic Process Positive Regulation Of Intracellular Signal Transduction Alkanesulfonate Metabolic Process Regulation Of DNA Replication Cell Migration Response To Lipid Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Positive Regulation Of DNA Metabolic Process Gland Morphogenesis Positive Regulation Of Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neutrophil Aggregation Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Hair Follicle Cell Proliferation Astrocyte Activation Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Submandibular Salivary Gland Formation Actin Filament Branching
Tagcloud ?		a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac	alarmin alarmins allergic amplifiers arthritis biomarker collagen dermatitis imaging immunological inflammation irritative leishmaniasis local locally missing monitor optical phagocyte predict released reliable sensitive serves sub tailoring th1 valuable
Tagcloud (Difference) ?		a9 auscan australian canadian erythrocyte esr exploratory grades hand hip inverse joint kellgren knee lawrence mcmaster narrowing oa ontario osteoarthritis osteophytes sedimentation space stiffness structural sum synovial universities womac	alarmin alarmins allergic amplifiers arthritis biomarker collagen dermatitis imaging immunological inflammation irritative leishmaniasis local locally missing monitor optical phagocyte predict released reliable sensitive serves sub tailoring th1 valuable
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