ZNF496 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF496	RNF8
Description		zinc finger protein 496	ring finger protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		Generic Transcription Pathway	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Chromium levels ( 26025379) Platelet distribution width ( 32888494)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		22 interacting genes: ARR3 CBX3 JADE2 NR3C1 NSD1 PGBD1 POLR3D PPARG RAI1 RNF8 SCAND1 SSX3 SUMO2 SUMO3 SUPT5H TRIM28 ZKSCAN4 ZNF446 ZSCAN12 ZSCAN21 ZSCAN22 ZZZ3	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		84838	9025
HPRD ID		15805	11521
Ensembl ID		ENSG00000162714	ENSG00000112130
Uniprot IDs		Q96IT1	O76064
PDB IDs			2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Zinc Ion Binding Nucleus Chromatin Binding Nucleoplasm RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Sumoylation Chromatin Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein Tag Activity DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Ubiquitin-like Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Cellular Response To Dexamethasone Stimulus RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Nuclear Glucocorticoid Receptor Activity Transcription Coregulator Binding Chromatin Remodeling Response To Dexamethasone Regulation Of DNA Binding Negative Regulation Of RNA Metabolic Process Protein Modification By Small Protein Conjugation Heterochromatin Positive Regulation Of Metabolic Process Cellular Response To Glucocorticoid Stimulus Positive Regulation Of MiRNA Transcription Nuclear Receptor Activity Chromatin Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
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