RAE1 and BUB1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		RAE1	BUB1
Description		ribonucleic acid export 1	BUB1 mitotic checkpoint serine/threonine kinase
Image
GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
Interacting Genes		14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		8480	699
HPRD ID		11939	03907
Ensembl ID		ENSG00000101146	ENSG00000169679
Uniprot IDs		P78406	B4DYG2 O43683
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH	2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle
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