BUB1 and KNL1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		BUB1	KNL1
Description		BUB1 mitotic checkpoint serine/threonine kinase	kinetochore scaffold 1
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Knl1/Spc105 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity	Protein Binding Microtubule Binding
	Biological Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	Mitotic Sister Chromatid Segregation Acrosome Assembly Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Homologous Chromosome Orientation In Meiotic Metaphase I Protein Localization To Kinetochore Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510	6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		699	57082
HPRD ID		03907	10634
Ensembl ID		ENSG00000169679	ENSG00000137812
Uniprot IDs		B4DYG2 O43683	Q8NG31
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J	3SI5 4A1G 4NF9 4NFA 6CZO 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle	Outer Kinetochore Kinetochore Chromosome, Centromeric Region Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome Segregation Cell Division Negative Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric MIS12/MIND Type Complex Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Protein Serine Kinase Activity Meiotic Sister Chromatid Cohesion Regulation Of Sister Chromatid Segregation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Organelle Organization Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Attachment Of Spindle Microtubules To Kinetochore Regulation Of Chromosome Organization Protein Localization To Chromosome, Centromeric Region Sister Chromatid Cohesion Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Nucleus Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle
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