BUB1 and BUB3

Number of citations of the paper that reports this interaction (PubMedID 9660858)
50

Data Source:
HPRD (in vivo)

		BUB1	BUB3
Description		BUB1 mitotic checkpoint serine/threonine kinase	BUB3 mitotic checkpoint protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Mitotic Checkpoint Complex Bub1-bub3 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity	Protein Binding Ubiquitin Binding
	Biological Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Kinetochore Cell Division Meiotic Cell Cycle Regulation Of Chromosome Segregation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Body mass index ( 28892062) Childhood asthma exacerbations in long-acting beta2-agonist treatment ( 33706416) Left-handedness ( 32989287) Lung volume ( 34128465) Menopause (age at onset) ( 24045676) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510	20 interacting genes: ANXA1 BUB1 BUB1B CEBPA CPNE1 EXOC3 HDAC1 HDAC2 PARP1 PARP2 PSTPIP1 PTEN RBBP7 REXO4 RPL37A SUGT1 THRA TOP1 UBA1 WBP4
Entrez ID		699	9184
HPRD ID		03907	04761
Ensembl ID		ENSG00000169679	ENSG00000154473
Uniprot IDs		B4DYG2 O43683	A0A140VJF3 O43684
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle	Nucleoplasm Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway NAD+-protein-serine ADP-ribosyltransferase Activity Nucleus NuRD Complex DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Sin3-type Complex Protein Lysine Delactylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Cell Fate Specification Fungiform Papilla Formation Chromatin Remodeling Meiotic Sister Chromatid Cohesion, Centromeric NF-kappaB Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Chromatin Binding Hair Follicle Placode Formation Histone Deacetylase Binding Histone Deacetylase Complex Circadian Rhythm Macromolecule Metabolic Process Regulation Of Cell Fate Commitment Regulation Of Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Response To Temperature Stimulus Chromatin Organization Chromosome Organization Positive Regulation Of Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Developmental Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Circadian Regulation Of Gene Expression Protein Auto-ADP-ribosylation Positive Regulation Of Developmental Process Meiotic Sister Chromatid Cohesion Cytosol NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of Stem Cell Population Maintenance Response To Steroid Hormone NAD+-protein-aspartate ADP-ribosyltransferase Activity Protein Lysine Deacetylase Activity Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Component Organization Regulation Of Stem Cell Differentiation Eyelid Development In Camera-type Eye Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
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