RAE1 and NUMA1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down)

		RAE1	NUMA1
Description		ribonucleic acid export 1	nuclear mitotic apparatus protein 1
Image
GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cell Cortex Membrane Lateral Plasma Membrane Nuclear Matrix Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	Structural Molecule Activity Protein Binding Microtubule Binding Lipid Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Drugs
Diseases
GWAS			Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1	26 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 RNF10 SMC1A SUMO2 TERF1 TERF2 TNKS USP7 YEATS4 YWHAQ
Entrez ID		8480	4926
HPRD ID		11939	01236
Ensembl ID		ENSG00000101146	ENSG00000137497
Uniprot IDs		P78406	Q14980 Q3SYK8
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH	3RO2 5GXW 6HC2 6QJA
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	Cell Division Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeleton Regulation Of Cell Cycle Spindle Pole Mitotic Spindle Pole Regulation Of Cell Cycle Process Regulation Of Telomere Capping Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Protein Localization To Cell Periphery Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cell Cortex Nucleoplasm Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cortical Actin Cytoskeleton Organization Mitotic Spindle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Cohesin Complex Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex BRISC Complex Regulation Of Mitotic Spindle Organization Positive Regulation Of Metabolic Process Centrosome Cortical Cytoskeleton Organization Regulation Of Organelle Organization Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Nuclear Matrix Mitotic Cohesin Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Cell Cycle Process Establishment Of Sister Chromatid Cohesion Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding
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