BUB1 and SFRP2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BUB1	SFRP2
Description		BUB1 mitotic checkpoint serine/threonine kinase	secreted frizzled related protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity	Fibronectin Binding Integrin Binding Enzyme Activator Activity Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity
	Biological Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	Regulation Of Cell Growth Branching Involved In Blood Vessel Morphogenesis Somitogenesis Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Mesodermal Cell Fate Specification Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Male Sexual Characteristics Digestive Tract Morphogenesis Stem Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS			Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221 33593615) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510	15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4
Entrez ID		699	6423
HPRD ID		03907	16041
Ensembl ID		ENSG00000169679	ENSG00000145423
Uniprot IDs		B4DYG2 O43683	A0A140VJU3 B3KSM5 Q96HF1
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle	Branching Involved In Ureteric Bud Morphogenesis Tube Morphogenesis Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Negative Regulation Of Neurogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Development Cellular Response To Indole-3-methanol Morphogenesis Of A Branching Epithelium Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Morphogenesis Of A Branching Structure Response To Indole-3-methanol Mesendoderm Development Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Cell Differentiation Tissue Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Flotillin Complex Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Kidney Development Axis Specification Neuron Projection Development Gamma-catenin Binding Mesonephros Development Animal Organ Morphogenesis Regionalization Gland Development Negative Regulation Of Cell Development Cardiac Conduction System Development Mesenchymal To Epithelial Transition Canonical Wnt Signaling Pathway Animal Organ Development Stem Cell Differentiation Anatomical Structure Arrangement Mesenchymal Cell Differentiation Positive Regulation Of Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Male Gonad Development Morphogenesis Of An Epithelium Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Central Nervous System Neuron Differentiation Regulation Of Neurogenesis Cell Projection Organization Gonad Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?