BUB1 and RDH12

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BUB1	RDH12
Gene Name		BUB1 mitotic checkpoint serine/threonine kinase	retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleoplasm Cytoplasm Cytosol Membrane	Intracellular Photoreceptor Inner Segment Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Retinol Dehydrogenase Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Cell Proliferation Viral Process Cell Division Regulation Of Chromosome Segregation Spindle Assembly Checkpoint Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Retinoid Metabolic Process Visual Perception Phototransduction, Visible Light Retinol Metabolic Process Photoreceptor Cell Maintenance Oxidation-reduction Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Diseases associated with visual transduction
Drugs			Vitamin A
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BUB1B BUB3 CASC5 CDC20 CDK1 CRK EIF4EBP1 HDAC1 PLK1 RAE1 RDH12 SVIL	3 interactors: BUB1 MAP1LC3A RBPMS
Entrez ID		699	145226
HPRD ID		03907	10585
Ensembl ID		ENSG00000169679	ENSG00000139988
Uniprot IDs		B4DYG2 E9PC26 F5GXI5 O43683	Q96NR8
PDB IDs		2LAH 3E7E 4A1G
Enriched GO Terms of Interacting Partners?		Spindle Assembly Checkpoint Spindle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Checkpoint Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Nuclear Division Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Cell Division Regulation Of Ubiquitin-protein Transferase Activity Protein Localization To Chromosome Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Cell Division Cell Cycle Process Negative Regulation Of Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Negative Regulation Of Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Protein Localization To Kinetochore Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Mitotic Cell Cycle Phase Transition Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Localization Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination	Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Sister Chromatid Cohesion Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Nitrogen Starvation Nucleophagy Mitochondrion Degradation Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Organelle Disassembly Negative Regulation Of Chromosome Segregation Autophagic Vacuole Assembly Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Pathway-restricted SMAD Protein Phosphorylation Macroautophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction
Tagcloud ?		aneuploidy apocrine arp2 beta1 biomarker box broad cytokinesis exploring forkhead foxm1 inside integrin luminal m1 microtubule mitosis mitotic notable partners pip polymerization prolactin proteomic rationale signature silencing talin tubulin	abca4 allelic audiogram bbs1 c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees sanger sscp tulp1 ush2a
Tagcloud (Difference) ?		aneuploidy apocrine arp2 beta1 biomarker box broad cytokinesis exploring forkhead foxm1 inside integrin luminal m1 microtubule mitosis mitotic notable partners pip polymerization prolactin proteomic rationale signature silencing talin tubulin	abca4 allelic audiogram bbs1 c2orf71 cerkl crb1 decisive deepen denaturing dhplc discern dystrophies electrophysiology fundus homozygosity hrm intrafamilial melt mlpa monoallelic ngs pde6b pedigrees sanger sscp tulp1 ush2a
Tagcloud (Intersection) ?