RAE1 and DHFR

Number of citations of the paper that reports this interaction (PubMedID 39480836)
55

Data Source:
BioGRID (unspecified method)

		RAE1	DHFR
Description		ribonucleic acid export 1	dihydrofolate reductase
Image
GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding MRNA Binding Dihydrofolate Reductase Activity Protein Binding Folic Acid Binding Oxidoreductase Activity NADP Binding NADPH Binding Sequence-specific MRNA Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	Tetrahydrobiopterin Biosynthetic Process One-carbon Metabolic Process Negative Regulation Of Translation Axon Regeneration Response To Methotrexate Dihydrofolate Metabolic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Regulation Of Removal Of Superoxide Radicals
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Metabolism of folate and pterines G1/S-Specific Transcription
Drugs			NADH Pyrimethamine Methotrexate Pemetrexed Gentamicin Proguanil Trimetrexate 2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine 2,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]Quinazoline 6-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-Diamine N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine 2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Sri-9662 2,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-Ium Sri-9439 Nicotinamide adenine dinucleotide phosphate Piritrexim Biopterin 2,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine Iclaprim Pralatrexate 5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE (4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness ( 32963231) Glomerular filtration rate (creatinine) ( 26831199) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Shingles ( 25297839) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1	11 interacting genes: AMFR ASGR1 CDC42 FKBP1A GKAP1 HSPD1 MDM2 RAE1 THBS1 TOMM20 TP53
Entrez ID		8480	1719
HPRD ID		11939	00519
Ensembl ID		ENSG00000101146	ENSG00000228716
Uniprot IDs		P78406	B0YJ76 B4DM58 P00374
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH	1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 2W3A 2W3B 2W3M 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW 3GI2 3GYF 3L3R 3N0H 3NTZ 3NU0 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZD 3OAF 3S3V 3S7A 4DDR 4G95 4KAK 4KBN 4KD7 4KEB 4KFJ 4M6J 4M6K 4M6L 4QHV 4QJC 5HPB 5HQY 5HQZ 5HSR 5HSU 5HT4 5HT5 5HUI 5HVB 5HVE 5SD6 5SD7 5SD8 5SD9 5SDA 5SDB 6A7C 6A7E 6DAV 6DE4 6VCJ 7ESE 7XI7 8WGN
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	GBD Domain Binding Protein Transmembrane Transport Cellular Response To Actinomycin D Migrasome Response To Actinomycin D Protein Localization To Mitochondrion Cellular Response To UV-C Intracellular Signaling Cassette TOM Complex Membrane Organization Mitochondrial Outer Membrane Translocase Complex 'de Novo' Protein Folding Cellular Response To Antibiotic P53 Binding Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Response To UV-C Protein-folding Chaperone Binding Ubiquitin Binding Cellular Response To Estrogen Stimulus Secretory Granule Mitochondrion Organization Response To Magnesium Ion Intracellular Signal Transduction Response To Xenobiotic Stimulus Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Protein Processing Mitochondrial Membrane Organization Negative Regulation Of Protein Maturation Protein Import Into Mitochondrial Matrix Positive Regulation Of Filopodium Assembly Amyloid Fibril Formation Protein Refolding Protein Localization To Organelle Positive Regulation Of Macrophage Activation Establishment Of Protein Localization To Organelle Cellular Response To Gamma Radiation Disordered Domain Specific Binding Negative Regulation Of Proteolysis CGMP-mediated Signaling Protein Transmembrane Transporter Activity Phagocytosis, Engulfment Protein Insertion Into Mitochondrial Membrane Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Establishment Of Protein Localization To Mitochondrial Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Protein-containing Complex Regulation Of Filopodium Assembly
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