RAE1 and CREBRF

		RAE1	CREBRF
Description		ribonucleic acid export 1	CREB3 regulatory factor
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Maternal Behavior Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Prolactin Signaling Pathway Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	CREB3 factors activate genes
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Body mass index ( 27455349) PR interval ( 32439900)
Interacting Genes		14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1	5 interacting genes: CREBL2 GRB7 MID2 NAA10 NAA11
Entrez ID		8480	153222
HPRD ID		11939	17308
Ensembl ID		ENSG00000101146	ENSG00000164463
Uniprot IDs		P78406	Q8IUR6
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Protein N-terminal-serine Acetyltransferase Activity NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity N-terminal Protein Amino Acid Acetylation Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Acyltransferase Activity Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Sister Chromatid Cohesion Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Microtubule Binding Internal Protein Amino Acid Acetylation
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