RAE1 and RBM38

		RAE1	RBM38
Description		ribonucleic acid export 1	RNA binding motif protein 38
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GO Annotations	Cellular Component	Spindle Pole Fibrillar Center Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytoskeleton Mitotic Spindle Pole	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Microtubule Binding Ubiquitin Binding	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus MRNA Export From Nucleus Nucleocytoplasmic Transport Cell Division Regulation Of Mitotic Spindle Organization	MRNA Processing Negative Regulation Of Cell Population Proliferation RNA Splicing Regulation Of Myotube Differentiation Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of RNA Splicing Regulation Of Cell Cycle 3'-UTR-mediated MRNA Stabilization
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glycated hemoglobin levels ( 34059833) Haemorrhoidal disease ( 33888516) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 29403010 28017375) Mean corpuscular volume ( 28017375 28453575 20139978 29403010) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Red blood cell traits ( 23222517) Response to statin therapy ( 20339536) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Type 2 diabetes ( 23300278)
Interacting Genes		14 interacting genes: BDKRB1 BUB1 CEBPA DDX24 DHFR EIF4ENIF1 HTR2B KLRC4 KLRK1 NUMA1 NUP98 NXF1 RNU1-1 TRF-GAA1-1	4 interacting genes: HNRNPH1 MDM2 RCHY1 ZC3H10
Entrez ID		8480	55544
HPRD ID		11939	15268
Ensembl ID		ENSG00000101146	ENSG00000132819
Uniprot IDs		P78406	Q9H0Z9
PDB IDs		3MMY 4OWR 7F60 7F90 7VPG 7VPH	2CQD 6JVX 6JVY
Enriched GO Terms of Interacting Partners?		MRNA Binding Positive Regulation Of Chromosome Organization Kinase Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Peptide Binding Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Methotrexate Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Nuclear Export Telomere Tethering At Nuclear Periphery Import Into Nucleus Protein Import Into Nucleus Protein Serine Kinase Activity (using GTP As Donor) Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity DNA Strand Displacement Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Prolactin Signaling Pathway Response To Dexamethasone Protein Localization To Nucleus	Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process P53 Binding Response To Formaldehyde Protein Autoubiquitination Ubiquitin Binding Cellular Response To Vitamin B1 Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Splicing Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Vitamin B1 NEDD8 Ligase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Actinomycin D Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Water-immersion Restraint Stress Traversing Start Control Point Of Mitotic Cell Cycle Cellular Response To Actinomycin D Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To UV-C Error-free Translesion Synthesis Receptor Serine/threonine Kinase Binding Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Ubiquitin-protein Transferase Activity Negative Regulation Of MiRNA Processing Atrial Septum Development Fibroblast Activation Peroxisome Proliferator Activated Receptor Binding Cellular Response To Antibiotic 5S RRNA Binding Regulation Of Proteolysis Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To UV-C Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of MiRNA Processing Regulation Of Regulatory NcRNA Processing Cellular Response To Estrogen Stimulus Response To Magnesium Ion RNA Binding Poly(U) RNA Binding Nucleus SUMO Transferase Activity Endocardial Cushion Morphogenesis Response To Ether
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