BUB1 and TMEFF1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BUB1	TMEFF1
Description		BUB1 mitotic checkpoint serine/threonine kinase	transmembrane protein with EGF like and two follistatin like domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity	Receptor Ligand Inhibitor Activity
	Biological Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	Host-mediated Suppression Of Symbiont Invasion Symbiont Entry Into Host Cell
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Familial squamous cell lung carcinoma ( 29924316)
Interacting Genes		64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510	10 interacting genes: APC BUB1 CCR1 CDKN2A DLC1 DYRK1A FLCN MLH3 PTEN PTPRJ
Entrez ID		699	8577
HPRD ID		03907	04570
Ensembl ID		ENSG00000169679	ENSG00000241697
Uniprot IDs		B4DYG2 O43683	Q8IYR6
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle	Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphorylation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cellular Component Organization Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Junction Assembly Negative Regulation Of Protein Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Protein Modification Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Gamma-catenin Binding Ruffle Membrane Beta-catenin Binding Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Focal Adhesion Assembly Regulation Of Phosphorylation Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cytoskeleton Organization Regulation Of Cell Communication Regulation Of Cell Cycle Phase Transition Regulation Of Signaling Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Catalytic Activity Cell Junction Organization Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Migration
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