BUB1 and ZNF189

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		BUB1	ZNF189
Description		BUB1 mitotic checkpoint serine/threonine kinase	zinc finger protein 189
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Generic Transcription Pathway
Drugs
Diseases
GWAS
Interacting Genes		64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510	15 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 RBM11 SMAD4 SRC STK11
Entrez ID		699	7743
HPRD ID		03907	11930
Ensembl ID		ENSG00000169679	ENSG00000136870
Uniprot IDs		B4DYG2 O43683	A0A087X0K2 B7ZLK9 O75820
PDB IDs		2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle	Regulation Of Cell Development Gland Development Animal Organ Morphogenesis Protein Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process Axis Specification Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Animal Organ Development Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Odontogenesis Cell Surface Receptor Signaling Pathway Cell Population Proliferation Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Gene Expression Nucleotide Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Centromeric Sister Chromatid Cohesion Cell Differentiation Regulation Of Wnt Signaling Pathway Reproductive Process Negative Regulation Of Developmental Process Negative Regulation Of Cell Motility Protein Phosphorylation LRR Domain Binding ATP Binding Regulation Of Cellular Component Organization Negative Regulation Of Locomotion Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Negative Regulation Of Wnt Signaling Pathway Mesendoderm Development Phosphorylation Regulation Of Intracellular Signal Transduction Mitral Valve Morphogenesis Negative Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Developmental Process
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