NFKBIE and IL1A

Number of citations of the paper that reports this interaction (PubMedID 10998424)
0

Data Source:
HPRD (in vitro)

		NFKBIE	IL1A
Description		NFKB inhibitor epsilon	interleukin 1 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Sequestering Activity	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process		Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Intracellular Sodium Ion Homeostasis Apoptotic Process Response To Stress Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cell Division Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of NF-kappaB in B cells	Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases		Hodgkin lymphoma	Graft-versus-host disease
GWAS		Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		4794	3552
HPRD ID		05181	00988
Ensembl ID		ENSG00000146232	ENSG00000115008
Uniprot IDs		O00221 Q7LC14 Q96F31	P01583
PDB IDs			2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch	Interleukin-1 Binding Interleukin-1 Receptor Activity Interleukin-1-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Response To Cytokine Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Interleukin-1, Type I, Activating Receptor Activity Interleukin-33 Receptor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Alpha Production Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin AIM2 Inflammasome Complex IPAF Inflammasome Complex Calpain Complex Viral Penetration Into Host Nucleus Mammary Gland Involution Cysteine-type Peptidase Activity Cytokine Precursor Processing Positive Regulation Of Neutrophil Extravasation Somite Specification Granulocyte Colony-stimulating Factor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Peptide
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