MEGF10 and CEP57

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		MEGF10	CEP57
Gene Name		multiple EGF-like-domains 10	centrosomal protein 57kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Integral Component Of Membrane Basolateral Plasma Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Microtubule Microtubule Cytoskeleton
	Molecular Function		Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Protein Homodimerization Activity Gamma-tubulin Binding
	Biological Process	Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Homotypic Cell-cell Adhesion Recognition Of Apoptotic Cell Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Muscle Cell Development	Protein Import Into Nucleus, Translocation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Microtubule Anchoring Protein Homooligomerization
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		22 interactors: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 HDAC4 ITSN2 KIAA1598 MCF2L2 RANBP10 SART3 SCAPER SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1	15 interactors: APP CEP63 CTAGE5 FGF2 GCC1 KRT13 KRT15 KRT31 KRT40 MAGEA2B MEGF10 MYC RALBP1 TFIP11 UIMC1
Entrez ID		84466	9702
HPRD ID		14384	16261
Ensembl ID		ENSG00000145794	ENSG00000166037
Uniprot IDs		Q96KG7	F5GYW0 Q86XR8
PDB IDs			4L0R
Enriched GO Terms of Interacting Partners?		Organelle Organization Cellular Component Assembly Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of Histone Deubiquitination Mitochondrial Alanyl-tRNA Aminoacylation RNA Splicing, Via Transesterification Reactions Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Cellular Macromolecular Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cis Assembly Of Pre-catalytic Spliceosome	Response To Radiation Positive Regulation Of Catalytic Activity Tissue Development Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Spliceosomal Complex Disassembly Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Satellite Cell Proliferation Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Response To DNA Damage Stimulus Ureteric Bud Morphogenesis Nephron Morphogenesis Developmental Process Renal Tubule Morphogenesis Skeletal Muscle Cell Proliferation Synaptic Growth At Neuromuscular Junction Skeletal Muscle Satellite Cell Activation Fibroblast Apoptotic Process Regulation Of Catalytic Activity Renal Tubule Development Cellular Metal Ion Homeostasis Positive Regulation Of Metabolic Process Kidney Morphogenesis Histone H2A K63-linked Deubiquitination Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Collateral Sprouting In Absence Of Injury Cellular Cation Homeostasis Cellular Ion Homeostasis Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Metal Ion Homeostasis Positive Regulation Of Hydrolase Activity Cell Recognition Regulation Of Response To DNA Damage Stimulus Mesonephros Development Anatomical Structure Development Collateral Sprouting Axon Midline Choice Point Recognition Epithelium Development Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Notch Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Nephron Development Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Cellular Chemical Homeostasis Positive Regulation Of Peptidase Activity Transition Metal Ion Homeostasis
Tagcloud ?		adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles	accumulation associates cdk4 contributing cyclin d1 detail drives exit hinders import inactivation juxtanuclear maintain microtubule neoplastic nucleocytoplasmic prb prevents proliferating proper quiescence quiescent termed tlk trafficking translokin turn undue
Tagcloud (Difference) ?		adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles	accumulation associates cdk4 contributing cyclin d1 detail drives exit hinders import inactivation juxtanuclear maintain microtubule neoplastic nucleocytoplasmic prb prevents proliferating proper quiescence quiescent termed tlk trafficking translokin turn undue
Tagcloud (Intersection) ?