MEGF10 and CUL7

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		MEGF10	CUL7
Gene Name		multiple EGF-like-domains 10	cullin 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Integral Component Of Membrane Basolateral Plasma Membrane Cell Projection	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function		Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Homotypic Cell-cell Adhesion Recognition Of Apoptotic Cell Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Muscle Cell Development	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Dendrite Morphogenesis
Pathways			IRE1alpha activates chaperones Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		22 interactors: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 HDAC4 ITSN2 KIAA1598 MCF2L2 RANBP10 SART3 SCAPER SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1	7 interactors: COMMD1 FBXW8 MEGF10 PLXNB3 RBX1 SKP1 UBE2M
Entrez ID		84466	9820
HPRD ID		14384	09901
Ensembl ID		ENSG00000145794	ENSG00000044090
Uniprot IDs		Q96KG7	Q14999
PDB IDs			2JNG
Enriched GO Terms of Interacting Partners?		Organelle Organization Cellular Component Assembly Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome Positive Regulation Of Histone Deubiquitination Mitochondrial Alanyl-tRNA Aminoacylation RNA Splicing, Via Transesterification Reactions Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Cellular Macromolecular Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cis Assembly Of Pre-catalytic Spliceosome	Protein Neddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Activation Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Lamellipodium Assembly Regulation Of Protein Ubiquitination Negative Regulation Of Sodium Ion Transmembrane Transport Skeletal Muscle Satellite Cell Differentiation Recognition Of Apoptotic Cell Plasma Membrane To Endosome Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Cell Surface Histone H2A Monoubiquitination Negative Regulation Of Sodium Ion Transport Histone H2A Ubiquitination Phagocytosis, Recognition Regulation Of Protein Catabolic Process Spongiotrophoblast Layer Development
Tagcloud ?		adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles	112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Difference) ?		adhere adopt ap2 ap50 associating autoimmunity ced cerebellum clathrin clearing coated colocalized corpses deeper dishes elucidating engulfment flat immunoblot irregular mirrored mosaic nematode ortholog pits stellate ubiquitinated unusually vacuoles	112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected
Tagcloud (Intersection) ?