MEGF10 and GULP1

Number of citations of the paper that reports this interaction (PubMedID 17643423)
0

Data Source:
BioGRID (pull down)

		MEGF10	GULP1
Description		multiple EGF like domains 10	GULP PTB domain containing engulfment adaptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Plasma Membrane Membrane Cell Projection	Cytoplasm
	Molecular Function	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding
	Biological Process	Phagocytosis Cell Adhesion Muscle Organ Development Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Vesicle-mediated Transport Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Cell Development Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation	Lipid Transport Phagocytosis Phagocytosis, Engulfment Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Bone mineral content ( 31790847) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311) Initial pursuit acceleration ( 29064472) Response to antipsychotic treatment in schizophrenia ( 29503163)	Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		24 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHANK3 SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1	6 interacting genes: CREB3L2 EPS8 LRP1 MEGF10 SMC2 SNCA
Entrez ID		84466	51454
HPRD ID		14384	12181
Ensembl ID		ENSG00000145794	ENSG00000144366
Uniprot IDs		Q96KG7	A0A8V8TQW5 H7BZV7 Q9UBP9
PDB IDs			6ITU
Enriched GO Terms of Interacting Partners?		Cytoplasm	Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Scavenger Receptor Activity Apoptotic Cell Clearance Positive Regulation Of Cellular Component Organization Adult Locomotory Behavior Regulation Of Organelle Organization Receptor Internalization Positive Regulation Of Transcytosis Vesicle-mediated Transport Endocytosis Positive Regulation Of Protein Localization To Cell Periphery Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phagocytosis Regulation Of Cytoskeleton Organization Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Growth Cone Negative Regulation Of Protein-containing Complex Assembly Import Into Cell Cell Activation Lipoprotein Particle Receptor Binding Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Adult Behavior Positive Regulation Of Endocytosis Regulation Of Protein Localization To Cell Periphery Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Myoblast Development Receptor-mediated Endocytosis Cell Cortex Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Skeletal Muscle Satellite Cell Proliferation
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