MEGF10 and SCAPER

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		MEGF10	SCAPER
Description		multiple EGF like domains 10	S-phase cyclin A associated protein in the ER
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Plasma Membrane Membrane Cell Projection	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Nuclear Speck Sperm Head Ooplasm
	Molecular Function	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding	Nucleic Acid Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Phagocytosis Cell Adhesion Muscle Organ Development Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Vesicle-mediated Transport Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Cell Development Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation	Ovarian Follicle Development Antral Ovarian Follicle Growth Spermatogenesis Retina Development In Camera-type Eye Seminiferous Tubule Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Appendicular lean mass ( 33097823) Bone mineral content ( 31790847) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311) Initial pursuit acceleration ( 29064472) Response to antipsychotic treatment in schizophrenia ( 29503163)	Appendicular lean mass ( 33097823) Bitter alcoholic beverage consumption ( 31046077) Clostridioides difficle infection in antibiotics-users ( 33841421) Estimated glomerular filtration rate ( 31152163) Late-onset Alzheimer's disease ( 27770636) Neonatal white matter microstructure ( 33009551) Neurociticism ( 29500382) Recalcitrant atopic dermatitis ( 25935106) Urate levels ( 31578528)
Interacting Genes		24 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHANK3 SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1	4 interacting genes: APPL1 CALM1 CELSR3 MEGF10
Entrez ID		84466	49855
HPRD ID		14384	11704
Ensembl ID		ENSG00000145794	ENSG00000140386
Uniprot IDs		Q96KG7	Q9BY12
PDB IDs			8BPO
Enriched GO Terms of Interacting Partners?		Cytoplasm	Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cell Projection Dopaminergic Neuron Axon Guidance Serotonergic Neuron Axon Guidance Positive Regulation Of Pinocytosis Positive Regulation Of Macropinocytosis Macropinosome Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adiponectin-activated Signaling Pathway Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Complement Component C1q Complex Binding Myoblast Development Skeletal Muscle Satellite Cell Activation Positive Regulation Of Melanin Biosynthetic Process Regulation Of Voltage-gated Calcium Channel Activity Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Melanin Biosynthetic Process Early Phagosome Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Skeletal Muscle Cell Proliferation Phagocytosis, Recognition Myoblast Migration Positive Regulation Of Myoblast Proliferation Negative Regulation Of Transport Regulation Of Cell Communication By Electrical Coupling Response To Hepatocyte Growth Factor Endocytosis Protein Phosphatase Activator Activity Calyx Of Held Plasma Membrane Cell-cell Adhesion
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