CEP57 and KRT8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP57	KRT8
Description		centrosomal protein 57	keratin 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding Scaffold Protein Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Protein Homooligomerization	Tumor Necrosis Factor-mediated Signaling Pathway Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Keratinization Formation of the cornified envelope Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells
Drugs			Tenecteplase Lanoteplase Copper
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 24390342 30423114) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Opioid dependence (time to event) ( 34124712) Prostate cancer ( 21743057) Sick sinus syndrome ( 33580673)
Interacting Genes		47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	53 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KIFC3 KPNA2 KRT13 KRT15 KRT16 KRT18 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT35 KRT36 KRT37 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 OGT PIWIL2 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2
Entrez ID		9702	3856
HPRD ID		16261	01015
Ensembl ID		ENSG00000166037	ENSG00000170421
Uniprot IDs		F5GYW0 Q86XR8	P05787 Q7L4M3
PDB IDs		4L0R 8IBH	7K3C 7K3X 7K3Y
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Epithelial Cell Differentiation Keratinization Negative Regulation Of Protein Acetylation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Post-translational Protein Modification De Novo Centriole Assembly Structural Molecule Activity DNA-binding Transcription Factor Binding Protein Binding Regulation Of Protein Ubiquitination Organelle Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Intermediate Filament Cytoskeleton Negative Regulation Of Protein Sumoylation Chromatin Organization Positive Regulation Of Neural Precursor Cell Proliferation B Cell Apoptotic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Fate Commitment Positive Regulation Of Ubiquitin-protein Transferase Activity Intracellular Signal Transduction Tissue Morphogenesis Centriole	Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Epithelial Cell Differentiation Cytoskeleton Organization Cytoskeleton Supramolecular Fiber Organization Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Organelle Organization Developmental Process Cytosol Extracellular Exosome MAP Kinase Activity Schwann Cell Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Desmosome ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Response To Mechanical Stimulus Insulin-like Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Hair Cycle Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Tissue Development Structural Constituent Of Cytoskeleton Pseudopodium Protein Kinase Activity Interleukin-34-mediated Signaling Pathway Cornified Envelope Protein Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cyclase Activity Face Development Epidermal Growth Factor Receptor Signaling Pathway Glial Cell Development Regulation Of Golgi Inheritance Response To Muscle Stretch
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