CEP57 and TXLNA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP57	TXLNA
Description		centrosomal protein 57	taxilin alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Centriolar Satellite	Extracellular Region Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding Syntaxin Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Protein Homooligomerization	Exocytosis B Cell Activation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Other interleukin signaling
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 24390342 30423114) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	95 interacting genes: AXIN2 AZI2 BIN3 BRCA1 BRMS1L BTF3 BTF3L4 CBY2 CCDC112 CCDC136 CCDC146 CCDC196 CCDC33 CCDC57 CCHCR1 CDC5L CDR2 CEBPA CEP44 CEP57 CEP57L1 CEP63 CFAP53 DEUP1 DMAP1 DRC4 DTNB EIF4ENIF1 EPN2 FAM81A FAM9A GOLGA2 GOLGA6A GORASP2 HAUS3 HYPK IKBKG KANK2 KIAA1328 KRT13 KRT15 KRT20 KRT24 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRT75 LCA5 LZTS1 MBIP MCC MEOX1 MEOX2 MIS18A NACA NDC80 NKAPD1 NMI NSMCE2 NUP62 OLIG2 PIAS2 PPFIA1 PPP1R13B PRDM16 PRPF3 RASSF8 RCOR3 RINT1 SIKE1 SLC25A21-AS1 SMARCE1 SNCA SNF8 SORBS3 SREK1 STMN2 STX1A STX1B STX3 STX4 TBC1D1 TCL1A TFIP11 TNIP1 TP53BP2 TTC33 TXLNB USHBP1 UTP14C WASHC1 WASHC3
Entrez ID		9702	200081
HPRD ID		16261	09408
Ensembl ID		ENSG00000166037	ENSG00000084652
Uniprot IDs		F5GYW0 Q86XR8	P40222
PDB IDs		4L0R 8IBH
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Epithelial Cell Differentiation Keratinization Negative Regulation Of Protein Acetylation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Post-translational Protein Modification De Novo Centriole Assembly Structural Molecule Activity DNA-binding Transcription Factor Binding Protein Binding Regulation Of Protein Ubiquitination Organelle Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Intermediate Filament Cytoskeleton Negative Regulation Of Protein Sumoylation Chromatin Organization Positive Regulation Of Neural Precursor Cell Proliferation B Cell Apoptotic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Fate Commitment Positive Regulation Of Ubiquitin-protein Transferase Activity Intracellular Signal Transduction Tissue Morphogenesis Centriole	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Structural Molecule Activity Microtubule Organizing Center Organization Protein Binding Cytoskeleton Organization Centriole Assembly Centriole Centrosome Cycle Centriole Replication Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoplasm Membraneless Organelle Assembly Negative Regulation Of Protein Localization To Endoplasmic Reticulum SNARE Binding Microtubule-based Process HMG Box Domain Binding SNARE Complex Assembly Organelle Assembly SNAP Receptor Activity Nascent Polypeptide-associated Complex Tissue Morphogenesis SNARE Complex Exocytosis Cell Differentiation Negative Regulation Of Cell Cycle Cytosol Positive Regulation Of Neurotransmitter Secretion Identical Protein Binding Neurotransmitter Transport Regulation Of Cell Cycle Spindle Pole Centrosome Somite Specification De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Cellular Developmental Process Vesicle Docking De Novo Centriole Assembly Microtubule Binding Establishment Of Protein Localization Manchette Assembly Regulation Of Cytoskeleton Organization
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