CEP57 and AARD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP57	AARD
Description		centrosomal protein 57	alanine and arginine rich domain containing protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Protein Homooligomerization	Response To Testosterone
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 24390342 30423114) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	15 interacting genes: CENPQ CEP57 GRIPAP1 KIAA0753 KRT24 KRT27 LMO4 MAGEB4 NTAQ1 STX1A STX2 STX5 TFIP11 TSGA10 VPS37C
Entrez ID		9702	441376
HPRD ID		16261	18830
Ensembl ID		ENSG00000166037	ENSG00000205002
Uniprot IDs		F5GYW0 Q86XR8	B2RU19 Q4LEZ3
PDB IDs		4L0R 8IBH
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Epithelial Cell Differentiation Keratinization Negative Regulation Of Protein Acetylation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Post-translational Protein Modification De Novo Centriole Assembly Structural Molecule Activity DNA-binding Transcription Factor Binding Protein Binding Regulation Of Protein Ubiquitination Organelle Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Intermediate Filament Cytoskeleton Negative Regulation Of Protein Sumoylation Chromatin Organization Positive Regulation Of Neural Precursor Cell Proliferation B Cell Apoptotic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Fate Commitment Positive Regulation Of Ubiquitin-protein Transferase Activity Intracellular Signal Transduction Tissue Morphogenesis Centriole	SNARE Complex SNAP Receptor Activity SNARE Binding Vesicle Docking Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Organelle Membrane Fusion Vesicle Organization Organelle Fusion Presynaptic Active Zone Membrane Membrane Fusion Structural Molecule Activity Organelle Organization Organelle Localization Myosin Head/neck Binding Protein-N-terminal Glutamine Amidohydrolase Activity Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Intracellular Protein Transport Structural Constituent Of Skin Epidermis Endomembrane System Protein Transport Spliceosomal Complex Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Protein Localization To Kinetochore Negative Regulation Of Receptor Clustering Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Intermediate Filament Organization Membrane Organization Intracellular Protein Localization Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Ventral Spinal Cord Interneuron Differentiation U2-type Post-mRNA Release Spliceosomal Complex Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Establishment Of Protein Localization
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