CEP57 and CCDC185

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CEP57	CCDC185
Description		centrosomal protein 57	coiled-coil domain containing 185
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Centriolar Satellite
	Molecular Function	Protein Binding Microtubule Binding Fibroblast Growth Factor Binding Identical Protein Binding Protein Homodimerization Activity Gamma-tubulin Binding	Protein Binding
	Biological Process	Spermatid Development Fibroblast Growth Factor Receptor Signaling Pathway Protein Homooligomerization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Cognitive ability (MTAG) ( 29186694) Erosive tooth wear (severe vs non-severe) ( 29898447) Feeling worry ( 29500382) Intelligence (MTAG) ( 29326435) Rheumatoid arthritis ( 24390342 30423114) Sun-seeking behavior ( 32920024) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		47 interacting genes: AARD ABI2 APP ATPAF2 CCDC136 CCDC138 CCDC185 CCHCR1 CEP63 DEUP1 FBXL3 FGF2 GCC1 HSF2BP KDM1A KLC4 KRT13 KRT15 KRT31 KRT4 KRT40 KRT75 KRT8 KRT83 KRT86 LMO3 MAGEA2 MAGEA2B MEGF10 MIA2 MYC OGT OIP5 PKN1 PPP1R13B RABEP1 RALBP1 RASSF10 SH3BP5L SPDEF TEX12 TFIP11 TSGA10 TSPYL4 TXLNA TXLNB UIMC1	49 interacting genes: AMOTL2 BACH2 CADPS CALCOCO2 CBY2 CCDC136 CCDC85B CDR2L CEP44 CEP57 EVI5 EVI5L FAM161A GEMIN4 GOLGA2 GOLGA6L9 GRIPAP1 HSF2BP IKZF1 ISY1-RAB43 KRT15 KRT27 KRT35 KRT40 KRTAP10-7 KRTAP4-12 KXD1 LURAP1 MAGEA11 MAGEA2 MAGEA2B MAGEA6 MCC MDFI MID2 MKRN3 MTUS2 NAP1L2 NUTM1 PDLIM7 PKNOX2 PPP1R12C SPRED1 SPTA1 TBC1D1 TRAF1 TRIM27 VPS52 ZRANB1
Entrez ID		9702	164127
HPRD ID		16261	08761
Ensembl ID		ENSG00000166037	ENSG00000178395
Uniprot IDs		F5GYW0 Q86XR8	Q8N715
PDB IDs		4L0R 8IBH
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Epithelial Cell Differentiation Keratinization Negative Regulation Of Protein Acetylation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Post-translational Protein Modification De Novo Centriole Assembly Structural Molecule Activity DNA-binding Transcription Factor Binding Protein Binding Regulation Of Protein Ubiquitination Organelle Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Intermediate Filament Cytoskeleton Negative Regulation Of Protein Sumoylation Chromatin Organization Positive Regulation Of Neural Precursor Cell Proliferation B Cell Apoptotic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Fate Commitment Positive Regulation Of Ubiquitin-protein Transferase Activity Intracellular Signal Transduction Tissue Morphogenesis Centriole	Keratin Filament Cytoskeleton Intermediate Filament Structural Constituent Of Skin Epidermis Negative Regulation Of Protein Acetylation Intermediate Filament Organization Microtubule Binding Protein Binding Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytosol PML Body Negative Regulation Of Protein Sumoylation Histone Deacetylase Binding Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Viral Transcription Identical Protein Binding Suppression Of Viral Release By Host
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?