SHANK3 and ACE2

Number of citations of the paper that reports this interaction (PubMedID 34835087)
55

Data Source:
BioGRID (pull down)

		SHANK3	ACE2
Description		SH3 and multiple ankyrin repeat domains 3	angiotensin converting enzyme 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Plasma Membrane Cilium Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Brush Border Membrane Cell Projection Membrane Raft Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding	Virus Receptor Activity Endopeptidase Activity Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Peptidyl-dipeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Transporter Activator Activity
	Biological Process	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Angiotensin Maturation Angiotensin-mediated Drinking Behavior Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Proteolysis Tryptophan Transport Viral Life Cycle Receptor-mediated Endocytosis Of Virus By Host Cell Viral Translation Regulation Of Vasoconstriction Regulation Of Cell Population Proliferation Ceramide Biosynthetic Process Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Amino Acid Transport Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Membrane Fusion Negative Regulation Of ERK1 And ERK2 Cascade Blood Vessel Diameter Maintenance Entry Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of L-proline Import Across Plasma Membrane Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Neurexins and neuroligins Neurexins and neuroligins RET signaling	Metabolism of Angiotensinogen to Angiotensins Attachment and Entry Potential therapeutics for SARS Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Chloroquine Hydroxychloroquine SPP1148 Bromhexine N-(2-Aminoethyl)-1-aziridineethanamine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2	48 interacting genes: AGT AGTR1 AGTR2 APOE BTN3A1 BTN3A2 BTN3A3 CALM1 CAMP DEFA1 DEFA5 DLEU2 ELANE GHRL GRM2 H2AC4 HRH1 HSPA1A KDM1A LTF LYZ MAP4K3 MAS1 MAST1 MAST2 MMP14 NHERF1 NHERF2 NTS PARD3 PDZK1 PRMT5 PTPN3 SCRIB SHANK1 SHANK2 SHANK3 SHROOM2 SKP2 SLC6A19 SNX17 SNX27 TAMALIN TMPRSS11A TMPRSS11D TMPRSS2 UBR4 USP50
Entrez ID		85358	59272
HPRD ID		18979	02274
Ensembl ID		ENSG00000251322	ENSG00000130234
Uniprot IDs		Q9BYB0	A0A7I2V4H0 Q9BYF1
PDB IDs		6CPK 7C7I 7C7J	1R42 1R4L 2AJF 3D0G 3D0H 3D0I 3KBH 3SCI 3SCJ 3SCK 3SCL 6ACG 6ACJ 6ACK 6CS2 6LZG 6M0J 6M17 6M18 6M1D 6VW1 7A91 7A92 7A94 7A95 7A96 7A97 7A98 7BH9 7CT5 7DDO 7DDP 7DF4 7DMU 7DQA 7DRV 7DWX 7DX4 7DX5 7DX6 7DX7 7DX8 7DX9 7E7E 7EDJ 7EFP 7EFR 7EKC 7EKE 7EKF 7EKG 7EKH 7FDG 7FDH 7FDI 7FEM 7JVO 7KJ2 7KJ3 7KJ4 7KMB 7KMS 7KMZ 7KNB 7KNE 7KNH 7KNI 7L0N 7L7F 7LO4 7MJM 7MJN 7NXC 7P19 7P55 7P8I 7P8J 7PKI 7R0Z 7R10 7R11 7R12 7R1A 7RPV 7SN0 7SXX 7SXY 7SXZ 7SY0 7SY1 7SY2 7SY3 7SY4 7SY5 7SY6 7SY7 7SY8 7T9K 7T9L 7TEW 7TEX 7TEZ 7TF0 7TN0 7U0N 7UFK 7UFL 7V61 7V7Z 7V80 7V81 7V82 7V83 7V84 7V85 7V86 7V87 7V88 7V89 7V8A 7V8B 7VIB 7VX4 7VX5 7VX9 7VXA 7VXB 7VXC 7VXD 7VXF 7VXK 7VXM 7W98 7W99 7W9B 7W9C 7W9I 7WBL 7WBP 7WBQ 7WGB 7WGC 7WHH 7WK4 7WK5 7WK6 7WNM 7WPA 7WPB 7WPC 7WS8 7WS9 7WSA 7WVP 7WVQ 7XAZ 7XB0 7XB1 7XBF 7XBG 7XBH 7XCH 7XCI 7XCP 7XID 7XO7 7XO8 7XO9 7XWA 7Y1Y 7Y1Z 7Y20 7Y21 7Y75 7Y76 7Y9Z 7YA0 7YA1 7YDI 7YEG 7YHW 7YJ3 7YR2 7YR3 7YR4 7ZDQ 7ZF7 8AQS 8ASY 8B9P 8BFW 8BN1 8BYJ 8DF5 8DLJ 8DLK 8DLM 8DLN 8DLP 8DLQ 8DLU 8DLV 8DM5 8DM6 8DV1 8DV2 8E7M 8FXB 8FXC 8H06 8H5C 8HRK 8HRL 8HRN 8HRU 8I91 8I92 8I93 8I9B 8I9C 8I9D 8I9E 8I9F 8I9G 8I9H 8IF2 8IOU 8IOV 8JJE 8JWH 8JYN 8JYO 8JYP 8P2W 8P2X 8P2Y 8P2Z 8P30 8P31 8QSQ 8S9G 8SPH 8SPI 8TOQ 8TOR 8TOS 8TOT 8TOU 8UZE 8VKO 8VKP 8VQR 8WBY 8WBZ 8WDR 8WDS 8WDY 8WDZ 8WE0 8WE1 8WE4 8WGV 8WGW 8WHS 8WHU 8WHZ 8WLZ 8WM3 8WP8 8WRH 8WRL 8WRM 8WRO 8WSR 8WTD 8WTJ 8WYH 8XAL 8XLM 8XLN 8XN2 8XN3 8XN5 8XNF 8XNK 8XSF 8XSJ 8XUY 8XUZ 8XV0 8XV1 8XVM 8XXW 8XY9 8XYE 8XYG 8XYO 8Y16 8Y18 8Y6A 8YZB 8YZC 8YZD 8YZE 8Z3W 8Z4X 8Z64 8Z6A 8Z7B 8Z7P 8ZBQ 9FMM 9IU1 9IUP 9IUQ 9IUU 9JJ6
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization	Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Angiotensin Type II Receptor Activity Plasma Membrane Biological Process Involved In Interaction With Symbiont Killing By Host Of Symbiont Cells Killing Of Cells Of Another Organism Synaptic Receptor Adaptor Activity Positive Regulation Of Signaling Angiotensin-activated Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cytokine Production Signal Transduction Regulation Of System Process Defense Response To Fungus Positive Regulation Of Cell Communication Vascular Process In Circulatory System Response To Fungus Cell Killing Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Signaling Receptor Binding Nitric Oxide-cGMP-mediated Signaling Circulatory System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Signaling Positive Regulation Of Signal Transduction Serine-type Endopeptidase Activity Antimicrobial Humoral Response Defense Response To Gram-negative Bacterium G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Type 2 Metabotropic Glutamate Receptor Binding Positive Regulation Of Cytokine Production Positive Regulation Of Developmental Process Low-density Lipoprotein Particle Remodeling Localization Within Membrane Regulation Of Cell Communication Brush Border Membrane Defense Response To Gram-positive Bacterium Renin-angiotensin Regulation Of Aldosterone Production Nitric Oxide Mediated Signal Transduction Extracellular Exosome Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Synaptic Plasticity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Specific Granule Lumen Type 3 Metabotropic Glutamate Receptor Binding
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