SHANK3 and GOT1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		SHANK3	GOT1
Description		SH3 and multiple ankyrin repeat domains 3	glutamic-oxaloacetic transaminase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane	Nucleus Cytoplasm Cytosol Axon Terminus Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding	Catalytic Activity L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Protein Binding Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine Transaminase Activity
	Biological Process	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Amino Acid Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process L-aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Amino Acid Biosynthetic Process Response To Carbohydrate L-glutamate Catabolic Process To Aspartate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Malate-aspartate Shuttle Dicarboxylic Acid Metabolic Process Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus L-glutamate Biosynthetic Process Response To Transition Metal Nanoparticle
Pathways		Neurexins and neuroligins Neurexins and neuroligins RET signaling	Methionine salvage pathway Aspartate and asparagine metabolism Malate-aspartate shuttle
Drugs			Pyridoxal phosphate Aspartic acid Glutamic acid Cysteine Adapalene Maleic acid Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)	Aspartate aminotransferase levels ( 21900944 30718733) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2	7 interacting genes: ABI3BP AGTR1 CCR2 EGFR PC SHANK3 TMEM120A
Entrez ID		85358	2805
HPRD ID		18979	00687
Ensembl ID		ENSG00000251322	ENSG00000120053
Uniprot IDs		Q9BYB0	A0A140VK69 P17174
PDB IDs		6CPK 7C7I 7C7J	3II0 3WZF 6DNA 6DNB 6DND 6LIG
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization	Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Biological Process Involved In Interaction With Host Positive Regulation Of Synaptic Transmission, Glutamatergic Intracellular Signaling Cassette Angiotensin Type I Receptor Activity Multivesicular Body, Internal Vesicle Lumen Pyruvate Carboxylase Activity Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Bradykinin Receptor Binding Shc-EGFR Complex Viral RNA Genome Packaging Guanylate Kinase-associated Protein Clustering Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Cell Differentiation System Process Positive Regulation Of Inflammatory Response Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Biotin Binding Coenzyme A Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Synaptic Transmission CCR2 Chemokine Receptor Binding
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