SHANK3 and ABCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SHANK3	ABCC2
Description		SH3 and multiple ankyrin repeat domains 3	ATP binding cassette subfamily C member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding	Nucleotide Binding Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity ABC-type Xenobiotic Transporter Activity Bilirubin Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Negative Regulation Of Gene Expression Bile Acid And Bile Salt Transport Bilirubin Transport Heme Catabolic Process Xenobiotic Export From Cell Carboxylic Acid Transport Transmembrane Transport Transepithelial Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier Xenobiotic Transport Across Blood-brain Barrier
Pathways		Neurexins and neuroligins Neurexins and neuroligins RET signaling	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes DJS Aspirin ADME Paracetamol ADME Atorvastatin ADME
Drugs			ATP Sulfinpyrazone Azvudine
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 24737748 26151821) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum metabolite levels ( 33031748) Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 NHERF1 NHERF4 PDZK1 RDX SHANK3 TUBB3 UBQLN1
Entrez ID		85358	1244
HPRD ID		18979	03065
Ensembl ID		ENSG00000251322	ENSG00000023839
Uniprot IDs		Q9BYB0	Q92887
PDB IDs		6CPK 7C7I 7C7J	8IZQ 8IZR 8JX7 8JXQ 8JXU 8JY4 8JY5 9BR2 9BUK 9C12 9C2I
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization	Protein-membrane Adaptor Activity Protein Localization To Membrane Intracellular Protein Localization Protein Localization To Plasma Membrane Microvillus Assembly Protein Localization To Cell Periphery Microvillus Organization Localization Within Membrane Filopodium Apical Part Of Cell Cell Periphery Apical Plasma Membrane Microvillus Membrane Regulation Of Transport Stereocilium Brush Border Membrane Regulation Of Cellular Component Size Renal Phosphate Ion Absorption Negative Regulation Of Store-operated Calcium Channel Activity Guanylate Cyclase Inhibitor Activity Brush Border Extracellular Exosome NF-kappaB P50/p65 Complex PDZ Domain Binding Microvillus Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Cell Size Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Netrin Receptor Binding Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Guanylate Kinase-associated Protein Clustering ERAD Pathway Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex Regulation Of Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Diffusion Trapping Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Ornithine Decarboxylase Activity Putrescine Biosynthetic Process From Arginine, Via Ornithine Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Vitamin D Biosynthetic Process Signaling Receptor Binding Cellular Localization Regulation Of Monoatomic Ion Transport Scavenger Receptor Binding Stereocilium Base
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