SHANK3 and DLGAP4

Number of citations of the paper that reports this interaction (PMID 10527873)
22

Data Source:
BioGRID (two hybrid)

		SHANK3	DLGAP4
Gene Name		SH3 and multiple ankyrin repeat domains 3	discs, large (Drosophila) homolog-associated protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Junction Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane Neuronal Postsynaptic Density	Membrane Synapse
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding Identical Protein Binding Scaffold Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Synapse Assembly Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering N-methyl-D-aspartate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long Term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity	Cell-cell Signaling
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC SPTAN1	15 interactors: BIN1 DLG1 DLG3 DLG4 EXOC4 GRIN1 GRIN2D PLP2 PPP1R1B SH3GL2 SHANK2 SHANK3 SORBS2 SYNGAP1 UBC
Entrez ID		85358	22839
HPRD ID		18979	16826
Ensembl ID		ENSG00000251322	ENSG00000080845
Uniprot IDs		D7UT47 Q9BYB0	Q9Y2H0
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Phosphorylation Cell Projection Morphogenesis Cell Part Morphogenesis Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Neuron Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Morphogenesis Neuron Differentiation Cell Projection Organization Response To External Stimulus Signaling Locomotion Cell Communication Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Actin Filament Polymerization Movement Of Cell Or Subcellular Component Cellular Response To Fibroblast Growth Factor Stimulus Response To Hormone Regulation Of Cytoskeleton Organization Response To Fibroblast Growth Factor Generation Of Neurons Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurogenesis Anatomical Structure Morphogenesis Neurotrophin Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Cell Development	Receptor Clustering Learning Regulation Of Long-term Neuronal Synaptic Plasticity Single-organism Behavior Social Behavior Learning Or Memory Receptor Localization To Synapse Membrane Organization Cognition Synaptic Transmission Behavior Regulation Of Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Vocalization Behavior Protein Localization To Synapse Neuron Projection Development Cell-cell Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Nervous System Development Protein Localization To Membrane Positive Regulation Of Membrane Potential Neurogenesis Neuron Differentiation Cell Projection Organization Neurological System Process Cell Morphogenesis Involved In Differentiation Axon Guidance Adult Behavior Response To External Stimulus Locomotion Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Nucleotide Phosphorylation Cell Projection Morphogenesis Visual Learning Cell Part Morphogenesis Visual Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Axonogenesis Regulation Of Postsynaptic Membrane Potential Synapse Assembly Axon Development Associative Learning Regulation Of Membrane Potential
Tagcloud ?		18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Difference) ?		18f 5mg amygdala antidepressant aspartate baseline biomarker bipolar blind comparative completed correlates dendritic fdg hippocampus hypothesized inability ketamine limitations mri neuroimaging pathophysiology pet predicted rearrangement spine subanesthetic tesla tethering
Tagcloud (Intersection) ?