CARD11 and ZAP70

Number of citations: 0 (PubMedID 12154360)
Data Source: HPRD (in vivo)

		CARD11	ZAP70
Name		caspase recruitment domain family member 11	zeta chain of T cell receptor associated protein kinase 70
Structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Membrane CBM Complex Membrane Raft Extracellular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	GMP Kinase Activity Protein Binding CARD Domain Binding	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Immune System Process Signal Transduction Canonical NF-kappaB Signal Transduction B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Proliferation TORC1 Signaling B Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process Lymphocyte Activation GDP Metabolic Process Homeostasis Of Number Of Cells Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Adaptive Immune Response Immune System Process Protein Phosphorylation Immune Response Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Regulation Of MAPK Cascade Positive Thymic T Cell Selection Negative Thymic T Cell Selection Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration T Cell Aggregation T Cell Migration
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling	Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules RHOH GTPase cycle Nuclear events stimulated by ALK signaling in cancer
Drugs		None	Staurosporine Fostamatinib
Diseases		None	Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Asthma ( 34103634 ) Atopic dermatitis ( 23042114 ) Cadmium levels ( 26025379 ) Daytime sleep phenotypes ( 27126917 ) Dupuytren's disease ( 28886342 ) Intracranial aneurysm ( 29531279 ) Multiple sclerosis ( 24076602 31604244 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Ulcerative colitis ( 23128233 ) White matter integrity ( 23218918 )	Bipolar disorder ( 31043756 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cardiac Troponin-T levels ( 31014085 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Diastolic blood pressure ( 30224653 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70	67 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PELI1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1
Entrez ID		84433	7535
HPRD ID		06234	01495
Ensembl ID		ENSG00000198286	ENSG00000115085
Uniprot IDs		Q9BXL7	P43403
PDB IDs		4JUP 4LWD	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76 7SIY
GO Terms Enriched among Interactors		Intracellular Signal Transduction Immune System Process Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Serine Kinase Activity Protein Phosphorylation Immune Response-activating Signaling Pathway Regulation Of Immune Response Kinase Activity Phosphorylation Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Signal Transduction Activation Of Immune Response Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Immunological Synapse MAP Kinase Kinase Kinase Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Cytosol Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process JNK Cascade Positive Regulation Of CGAS/STING Signaling Pathway Lymphocyte Homeostasis Protein Modification Process Transferase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Anoikis Protein Serine/threonine Phosphatase Activity Kinase Activator Activity Positive Regulation Of T Cell Activation Phosphate-containing Compound Metabolic Process	Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Signal Transduction Regulation Of Lymphocyte Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Immune System Process Lymphocyte Activation Cell Activation Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune System Process Regulation Of T Cell Activation Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction T Cell Activation Intracellular Signal Transduction Activation Of Immune Response Plasma Membrane Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Membrane Raft Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Leukocyte Proliferation Regulation Of T Cell Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction SH3 Domain Binding Negative Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Lymphocyte Proliferation Positive Regulation Of Multicellular Organismal Process Mononuclear Cell Proliferation