CARD11 and BCL10

Number of citations of the paper that reports this interaction (PMID 11278692)
53

Data Source:
HPRD (in vivo, in vitro)

		CARD11	BCL10
Gene Name		caspase recruitment domain family, member 11	B-cell CLL/lymphoma 10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane T Cell Receptor Complex Membrane Raft Extracellular Vesicular Exosome	Immunological Synapse Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Plasma Membrane CBM Complex T Cell Receptor Complex Protein Complex Membrane Raft Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Guanylate Kinase Activity Protein Binding CARD Domain Binding	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Protein Kinase B Binding Protein Self-association NF-kappaB Binding
	Biological Process	Positive Regulation Of Cytokine Production Positive Regulation Of B Cell Proliferation T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation Nucleotide Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	B Cell Apoptotic Process Neural Tube Closure Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Response To Food Positive Regulation Of Mast Cell Cytokine Production Fc-epsilon Receptor Signaling Pathway Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of Phosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Protein Homooligomerization T Cell Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Protein-Protein Interactions		10 interactors: BCL10 IKBKG MAP3K7 PDPK1 PRKCB PRKCQ SH2D3C TAB1 WDR1 ZAP70	35 interactors: AKT1 ATM BIRC3 C9orf89 CARD10 CARD11 CARD14 CARD9 CASP9 CDK9 CHUK IKBKB IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NLRC4 PELI2 PRRG4 RIPK2 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 UBC UBE2N UBE2V2 USHBP1
Entrez ID		84433	8915
HPRD ID		06234	04625
Ensembl ID		ENSG00000198286	ENSG00000142867
Uniprot IDs		Q8TES3 Q9BXL7	O95999
PDB IDs
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune System Process Response To Stress Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell-cell Adhesion JNK Cascade Regulation Of Signal Transduction Phosphorylation Intracellular Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Toll-like Receptor Signaling Pathway Regulation Of Signaling Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Signal Transduction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Immune Response Immune System Process Pattern Recognition Receptor Signaling Pathway Defense Response Innate Immune Response-activating Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Activation Of Innate Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Activation Positive Regulation Of Innate Immune Response Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Intracellular Signal Transduction	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cell Death Regulation Of Signaling Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response Positive Regulation Of Immune Response Toll-like Receptor 9 Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Signal Transduction Immune Response Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway
Tagcloud ?		7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls splenic tnfaip3 tnfr traf3	adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Difference) ?		7q baffr characterise clustered cooperative deregulate doi exome frameshift genetics ighv1 inactivating indels klf2 kruppel leu lymphomagenesis marginal missense myd88 nonsense notch2 publication smzl smzls splenic tnfaip3 tnfr traf3	adaptor assembly carma1 cbm clustering clusters connecting cytosolic effector engagement ensure ikappab ikappabalpha ikk incompletely inhibiting kappab malt1 nf p62 recruited requires signalosome signalosomes tak1 tcr transiently translocated triggers
Tagcloud (Intersection) ?