EIF4G3 and VPS25

Number of citations of the paper that reports this interaction (PubMedID 35780119)
58

Data Source:
BioGRID (unspecified method)

		EIF4G3	VPS25
Description		eukaryotic translation initiation factor 4 gamma 3	vacuolar protein sorting 25 homolog
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	ESCRT II Complex Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Endosome Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding	Structural Molecule Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Spermatid Development Negative Regulation Of Autophagy Positive Regulation Of Translation	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Macroautophagy Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Membrane Fission
Pathways		ISG15 antiviral mechanism	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mean spheric corpuscular volume ( 32888494) Morning person ( 30696823) Postoperative acute renal failure after cardiac surgery ( 30678657) Red blood cell count ( 32888494) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		17 interacting genes: CAMK1 CTNND1 DDX19B EIF4A1 EIF4E HSPB1 LIG4 LSM3 MKNK1 PABPC1 PCNT PSMB6 RNF10 TRIM25 VAV2 VPS25 WDR37	24 interacting genes: APIP ASPG B9D2 BEND5 BPIFA1 CHMP6 CRLF3 EIF4G3 GPR35 LTB4R2 PICK1 REL RHOXF2 SDCBP2 SEPTIN14 SNCA SNF8 SPG21 SPRY2 SYCE1 TADA2A TRIM27 UBC VPS36
Entrez ID		8672	84313
HPRD ID		06802	14396
Ensembl ID		ENSG00000075151	ENSG00000131475
Uniprot IDs		A0A0A0MSA7 A0A804HJV5 A0A8I5QJH9 A0A8J9G7U8 B4DXR2 O43432 Q59GJ0	Q9BRG1
PDB IDs		1HU3	2ZME 3CUQ 3HTU
Enriched GO Terms of Interacting Partners?		Cytoplasmic Stress Granule Nucleus Cytoplasm RNA Cap Binding Eukaryotic Translation Initiation Factor 4F Complex Cytosol Calcium/calmodulin-dependent Protein Kinase Activity Extracellular Exosome RNA Binding Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Translation	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization ESCRT II Complex Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Lipid Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosome Organization Regulation Of Exosomal Secretion Negative Regulation Of Autophagy Endosomal Transport
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