EIF4G3 and EIF4A1

Number of citations of the paper that reports this interaction (PMID 9418880)
92

Data Source:
HPRD (in vivo, in vitro)

		EIF4G3	EIF4A1
Gene Name		eukaryotic translation initiation factor 4 gamma, 3	eukaryotic translation initiation factor 4A1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Cap Binding Translation Initiation Factor Activity Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	RNA Cap Binding Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Viral Process Cytokine-mediated Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Gene Expression Viral Process Cytokine-mediated Signaling Pathway Organ Regeneration Cellular Protein Metabolic Process
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Translation initiation complex formation Translation Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CAMK1 EIF4A1 EIF4E LIG4 MKNK1 PABPC1 VAV2	10 interactors: EIF4G1 EIF4G2 EIF4G3 LIG4 LPPR4 MAPK6 PAIP1 PRMT1 UCHL5 UPF2
Entrez ID		8672	1973
HPRD ID		06802	04030
Ensembl ID		ENSG00000075151	ENSG00000161960
Uniprot IDs		O43432 Q504Z1 Q59GJ0	P60842
PDB IDs		1HU3	2G9N 2ZU6 3EIQ
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Translational Initiation Regulation Of Translation MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression DNA Ligation Involved In DNA Recombination MRNA Metabolic Process Viral Process RNA Processing Translation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Synapse Structural Plasticity Cellular Macromolecule Catabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Apoptotic Process Establishment Of Integrated Proviral Latency Programmed Cell Death Cellular Response To Stimulus Nucleocytoplasmic Transport System Development Nuclear Transport Cell Death Death Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Synapse Structural Plasticity Response To Organic Substance Lymphoid Progenitor Cell Differentiation Positive Regulation Of Protein Export From Nucleus DNA Ligation Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Translational Initiation Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Translation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Metabolic Process Cellular Macromolecule Catabolic Process DNA Ligation Involved In DNA Recombination Cellular Protein Metabolic Process MRNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytokine-mediated Signaling Pathway Aromatic Compound Catabolic Process RNA 3'-end Processing Regulation Of Protein Metabolic Process Gene Expression MRNA Metabolic Process Viral Process Cellular Macromolecule Biosynthetic Process Cellular Response To Cytokine Stimulus Macromolecule Biosynthetic Process Negative Regulation Of Megakaryocyte Differentiation Protein Metabolic Process Lagging Strand Elongation Pro-B Cell Differentiation Response To Cytokine Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Establishment Of Integrated Proviral Latency Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency DNA Recombination T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Metabolic Process Catabolic Process Lymphoid Progenitor Cell Differentiation Peptidyl-arginine N-methylation Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Histone H4-R3 Methylation RNA Metabolic Process DNA Ligation Cellular Response To Stimulus
Tagcloud ?		absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral polysome profiling protease pta stromal t1d translation tuning	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		absent aminopeptidase anpep antigen autoregulatory controlling deaf1 deformed degrades diminished encodes fine histocompatibility ko lnscs lymph maintaining mhc nodes peripheral profiling protease pta stromal t1d translation tuning	classes constituents cycling cyclins dexd dysregulation eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 pdcd4 preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?		polysome