CASP10 and PRDX6

Number of citations of the paper that reports this interaction (PMID 20829884)
6

Data Source:
BioGRID (protein complementation assay)

		CASP10	PRDX6
Gene Name		caspase 10, apoptosis-related cysteine peptidase	peroxiredoxin 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome	Extracellular Space Cytoplasm Lysosome Cytosol Membrane Cytoplasmic Membrane-bounded Vesicle Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Antioxidant Activity Peroxiredoxin Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway	Response To Reactive Oxygen Species Response To Oxidative Stress Phospholipid Catabolic Process Hydrogen Peroxide Catabolic Process Oxidation-reduction Process
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System	Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	14 interactors: CASP10 CASP8 GPX4 HNF4G NCF2 NR4A1 ORM2 PAXIP1 PPARD RARA SUMO4 TERF1 TERF2IP UCHL5
Entrez ID		843	9588
HPRD ID		03458	03817
Ensembl ID		ENSG00000003400	ENSG00000117592
Uniprot IDs		Q92851	P30041
PDB IDs			1PRX
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death	Response To Steroid Hormone Intracellular Receptor Signaling Pathway Response To Lipid Response To Organic Cyclic Compound Steroid Hormone Mediated Signaling Pathway Response To Hormone Hormone-mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Stress Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Apoptotic Process DNA-templated Transcription, Initiation Response To Stimulus Regulation Of Cell Death Cellular Response To Hormone Stimulus Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Epithelial Cell Migration Response To Organic Substance Epithelium Migration Cellular Response To Organic Substance Response To Estradiol Regulation Of Telomere Maintenance Positive Regulation Of Intracellular Signal Transduction RNA-dependent DNA Replication Cellular Response To Lipid Cardiovascular System Development Response To Vitamin A Transcription, DNA-templated Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Ameboidal-type Cell Migration Telomere Maintenance Via Telomere Lengthening Developmental Process RNA Biosynthetic Process Regulation Of Chromosome Organization Response To Estrogen Adipose Tissue Development Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Programmed Cell Death Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cell Death Connective Tissue Development Macromolecule Biosynthetic Process Response To Activity Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn	1g accompanied activities altered bifunctional carcinogen ccl5 ccr5 clear colocalized cytokine definitive especially glutathione gpx ipla2 jak2 lung mice pathophysiological peroxidase promotes stat3 tg though transgenic tumors urethane validated
Tagcloud (Difference) ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn	1g accompanied activities altered bifunctional carcinogen ccl5 ccr5 clear colocalized cytokine definitive especially glutathione gpx ipla2 jak2 lung mice pathophysiological peroxidase promotes stat3 tg though transgenic tumors urethane validated
Tagcloud (Intersection) ?