CASP10 and NFKBIL1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CASP10	NFKBIL1
Name		caspase 10	NFKB inhibitor like 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Nucleus Nucleoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding	Protein Binding Transcription Regulator Inhibitor Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Negative Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Lipopolysaccharide
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	None
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Basal cell carcinoma ( 25855136 ) Chronic lymphocytic leukemia ( 23770605 28165464 ) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831 ) Mean corpuscular hemoglobin ( 32888494 )	Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Crohn's disease ( 23128233 ) Early chronic obstructive pulmonary disease in never smokers ( 33235445 ) Eosinophil count ( 32888494 ) Glycated hemoglobin levels ( 34059833 ) Height ( 28552196 ) Hematocrit ( 32888494 ) High light scatter reticulocyte count ( 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Malaria ( 31844061 ) Monocyte percentage of white cells ( 32888494 ) Neonatal lupus ( 20662065 ) Refractive error ( 32231278 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Sepsis (90-day mortality) ( 32592749 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Type 2 diabetes ( 30054458 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	6 interacting genes: ADIPOR1 AKAP19 CASP10 CLEC18C NME7 PEX14
Entrez ID		843	4795
HPRD ID		03458	07043
Ensembl ID		ENSG00000003400	ENSG00000204498
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	A0A0A0MRT5 A8K778 Q5STV6 Q9UBC1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process	None