CASP10 and CASP14

Number of citations of the paper that reports this interaction (PubMedID 9792675)
0

Data Source:
HPRD (in vivo)

		CASP10	CASP14
Description		caspase 10	caspase 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Proteolysis Epidermis Development Cell Differentiation Keratinization Positive Regulation Of Neuron Apoptotic Process Cornification
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 23770605 28165464) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5
Entrez ID		843	23581
HPRD ID		03458	05788
Ensembl ID		ENSG00000003400	ENSG00000105141
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	B2CIS9 P31944
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process	Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Peptidase Activity Positive Regulation Of Neuron Apoptotic Process Hydrolase Activity Proteolysis Protein Maturation Execution Phase Of Apoptosis Pyroptotic Inflammatory Response Protein Processing Death Effector Domain Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication NLRP1 Inflammasome Complex Positive Regulation Of Signaling Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Self Proteolysis Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Execution Phase Of Apoptosis Protein Autoprocessing Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Mechanical Stimulus Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Macrophage Differentiation Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction
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