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CASP10 and DSP
Number of citations of the paper that reports this interaction (PubMedID
15500642
)
0
Data Source:
HPRD
(in vitro)
CASP10
DSP
Description
caspase 10
desmoplakin
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
CD95 Death-inducing Signaling Complex
Ripoptosome
Cornified Envelope
Nucleus
Cytoplasm
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Fascia Adherens
Intercalated Disc
Membrane
Basolateral Plasma Membrane
Desmosome
Extracellular Exosome
Anchoring Junction
Ficolin-1-rich Granule Membrane
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
RNA Binding
Protein Kinase C Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Scaffold Protein Binding
Biological Process
Proteolysis
Apoptotic Process
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Protein Maturation
Execution Phase Of Apoptosis
Positive Regulation Of Execution Phase Of Apoptosis
Desmosome Organization
Ventricular Compact Myocardium Morphogenesis
Epidermis Development
Peptide Cross-linking
Keratinocyte Differentiation
Adherens Junction Organization
Wound Healing
Skin Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament Organization
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Regulation Of Heart Rate By Cardiac Conduction
Epithelial Cell-cell Adhesion
Cell-cell Adhesion
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Protein Localization To Cell-cell Junction
Pathways
TP53 Regulates Transcription of Caspase Activators and Caspases
FasL/ CD95L signaling
TRAIL signaling
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Apoptotic cleavage of cell adhesion proteins
Neutrophil degranulation
Keratinization
Formation of the cornified envelope
RND3 GTPase cycle
RND1 GTPase cycle
Drugs
Zinc
Artenimol
Zinc acetate
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
Striate palmoplantar keratoderma
Skin fragility-woolly hair syndrome
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Naxos disease and Carvajal syndrome
Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS
Alanine aminotransferase levels (
33547301
)
Basal cell carcinoma (
25855136
)
Chronic lymphocytic leukemia (
23770605
28165464
)
Chronic lymphocytic leukemia or rheumatoid arthritis (
31407831
)
Mean corpuscular hemoglobin (
32888494
)
Chronic obstructive pulmonary disease (
28166215
30804561
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Idiopathic pulmonary fibrosis (
29066090
31710517
)
Interstitial lung disease (
23583980
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Numerical cognitive ability (
31620175
)
PR interval (
32439900
)
Response to fenofibrate (triglyceride levels) (
27002377
)
Resting heart rate (
27798624
)
Interacting Genes
30 interacting genes:
BFAR
BID
CASP1
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8
CASP8AP2
CASP9
CCAR1
CFLAR
DEDD
DEDD2
DSP
ECE2
FADD
NFKBIL1
OIP5
PHF20L1
POLR2A
PRDX6
RB1
RIOK3
RYBP
TNFRSF1A
TRAF1
XIAP
36 interacting genes:
ARID3A
CASP10
CASP2
CASP4
CASP6
CASP7
CASP9
CDC42
CDH5
COL17A1
COPS6
DES
DSC1
ENO3
EVPL
H19
IVL
JUP
KRT1
KRT5
KRT6A
MTDH
PECAM1
PKP1
PKP2
PKP3
PKP4
PRKACA
PRKCE
PTEN
RNF10
TTC3
UCHL5
USP7
VIM
WEE2-AS1
Entrez ID
843
1832
HPRD ID
03458
00513
Ensembl ID
ENSG00000003400
ENSG00000096696
Uniprot IDs
A0A0S2Z3G5
A0A0S2Z3Z5
Q92851
A0AAQ5BH43
B4DKX6
P15924
PDB IDs
1LM5
1LM7
3R6N
5DZZ
Enriched GO Terms of Interacting Partners
?
Cell Death
Programmed Cell Death
Apoptotic Process
Cysteine-type Endopeptidase Activity
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Cysteine-type Peptidase Activity
Death Receptor Binding
Extrinsic Apoptotic Signaling Pathway
Protein Processing
Pyroptotic Inflammatory Response
Death-inducing Signaling Complex
Regulation Of Canonical NF-kappaB Signal Transduction
Execution Phase Of Apoptosis
Regulation Of Neuron Apoptotic Process
Neuron Apoptotic Process
Regulation Of Necroptotic Process
Cellular Response To Mechanical Stimulus
Protein Maturation
Regulation Of Programmed Necrotic Cell Death
Cell Surface Receptor Signaling Pathway
Peptidase Activity
Cellular Response To Staurosporine
Proteolysis
Epithelial Cell Apoptotic Process
Regulation Of Signal Transduction
Glial Cell Apoptotic Process
Positive Regulation Of Execution Phase Of Apoptosis
Response To Mechanical Stimulus
Response To Anesthetic
Ripoptosome
CD95 Death-inducing Signaling Complex
Response To Lipopolysaccharide
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Defense Response
Response To Molecule Of Bacterial Origin
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Response To Stress
Regulation Of Defense Response
Regulation Of Intracellular Signal Transduction
Response To Cobalt Ion
Regulation Of Apoptotic Signaling Pathway
Fibroblast Apoptotic Process
Cornified Envelope
Desmosome
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament
Cysteine-type Endopeptidase Activity
Cell-cell Junction Organization
Desmosome Organization
Cell Junction Assembly
Intermediate Filament Organization
Cysteine-type Peptidase Activity
Cell-cell Junction
Anchoring Junction
Desmosome Assembly
Cell Junction Organization
Positive Regulation Of Neuron Apoptotic Process
Cell-cell Junction Assembly
Cytoplasm
Peptidase Activity
Keratinization
Alpha-catenin Binding
Adherens Junction
Intermediate Filament Cytoskeleton
Cadherin Binding
Desmosome Maintenance
Cytoskeleton Organization
Cytosol
Peptide Cross-linking
Structural Constituent Of Skin Epidermis
Supramolecular Fiber Organization
Cell-cell Adhesion
Cell Adhesion
Epidermis Development
Cellular Component Assembly
Positive Regulation Of Signal Transduction
Regulation Of Neuron Apoptotic Process
Execution Phase Of Apoptosis
Proteolysis
Cellular Response To Staurosporine
Protein Metabolic Process
Protein Processing
Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
Protein Maturation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Periphery
Response To Indole-3-methanol
Cell Junction
Structural Constituent Of Cytoskeleton
Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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