CASP10 and OIP5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CASP10	OIP5
Gene Name		caspase 10, apoptosis-related cysteine peptidase	Opa interacting protein 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Chromocenter Cajal Body
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway	Nucleosome Assembly Mitotic Nuclear Division Cell Communication CENP-A Containing Nucleosome Assembly Cell Division
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System	Chromosome Maintenance Nucleosome assembly Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	21 interactors: ABL2 BRAF C1orf94 CASP10 CEP170P1 EIF4ENIF1 FOXJ1 GCC1 KDM1A KRT15 MIS18A NUP62 PEX19 RAF1 RARG SKIL TFIP11 TMPO TPM3 TRIP6 TSSK3
Entrez ID		843	11339
HPRD ID		03458	09352
Ensembl ID		ENSG00000003400	ENSG00000104147
Uniprot IDs		Q92851	O43482
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death	Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Cell Proliferation Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Signaling Regulation Of Endothelial Cell Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Component Assembly Positive Regulation Of Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation Central Tolerance Induction Spliceosomal Complex Disassembly Negative Regulation Of Lipid Binding Glomerular Parietal Epithelial Cell Development Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Central B Cell Tolerance Induction Death-inducing Signaling Complex Assembly Negative Regulation Of Small GTPase Mediated Signal Transduction Immune System Process Regulation Of Metabolic Process Developmental Process Regulation Of Binding Visual Learning Alpha-beta T Cell Differentiation Regulation Of MAPK Cascade Organ Development Negative Regulation Of Signal Transduction Activation Of MAPKK Activity Visual Behavior Regulation Of Cell Motility Alpha-beta T Cell Activation Cellular Response To Retinoic Acid Somatic Stem Cell Maintenance Regulation Of Ras Protein Signal Transduction Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation
Tagcloud ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?