CASP10 and CASP7

Number of citations of the paper that reports this interaction (PubMedID 8962078)
24

Data Source:
HPRD (in vitro)

		CASP10	CASP7
Description		caspase 10	caspase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Fibrillar Center Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding	RNA Binding Catalytic Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Regulation Of Transcription By RNA Polymerase II Proteolysis Apoptotic Process Heart Development Response To UV Protein Processing Protein Catabolic Process Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Ceramide Biosynthetic Process Striated Muscle Cell Differentiation Neuron Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Lymphocyte Apoptotic Process Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis Positive Regulation Of Plasma Membrane Repair
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs			Fica Emricasan Incadronic acid
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 23770605 28165464) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)	Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 22561518 27723757)
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HNRNPH1 HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A TRIM25 UBE4B VIM XIAP
Entrez ID		843	840
HPRD ID		03458	03457
Ensembl ID		ENSG00000003400	ENSG00000165806
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	A0A0A0MRL7 B4DWA2 P55210
PDB IDs			1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z 7WZS 8DGZ 8DJ3
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Cytosol Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleus Cytoplasm Intracellular Signal Transduction Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Cellular Component Organization Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Execution Phase Of Apoptosis Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cellular Response To Stress Myeloid Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Regulation Of Cell Communication Regulation Of Necroptotic Process Protein Metabolic Process Cysteine-type Endopeptidase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Protein Maturation Regulation Of Programmed Necrotic Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Protein Processing
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?