CASP10 and BFAR

Number of citations of the paper that reports this interaction (PubMedID 10716992)
46

Data Source:
HPRD (in vivo, in vitro)

		CASP10	BFAR
Description		caspase 10	bifunctional apoptosis regulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding	Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Caspase Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Protein Maturation Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of IRE1-mediated Unfolded Protein Response
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 23770605 28165464) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	12 interacting genes: BCL2 CASP10 CASP8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2N UBE2U UBE2W
Entrez ID		843	51283
HPRD ID		03458	16548
Ensembl ID		ENSG00000003400	ENSG00000103429
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	H3BMP2 Q9NZS9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cysteine-type Peptidase Activity Death Receptor Binding Extrinsic Apoptotic Signaling Pathway Protein Processing Pyroptotic Inflammatory Response Death-inducing Signaling Complex Regulation Of Canonical NF-kappaB Signal Transduction Execution Phase Of Apoptosis Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Regulation Of Necroptotic Process Cellular Response To Mechanical Stimulus Protein Maturation Regulation Of Programmed Necrotic Cell Death Cell Surface Receptor Signaling Pathway Peptidase Activity Cellular Response To Staurosporine Proteolysis Epithelial Cell Apoptotic Process Regulation Of Signal Transduction Glial Cell Apoptotic Process Positive Regulation Of Execution Phase Of Apoptosis Response To Mechanical Stimulus Response To Anesthetic Ripoptosome CD95 Death-inducing Signaling Complex Response To Lipopolysaccharide Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Defense Response Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Response To Stress Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Cobalt Ion Regulation Of Apoptotic Signaling Pathway Fibroblast Apoptotic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Proteolysis Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Catabolic Process Protein Modification Process Protein Metabolic Process Protein K48-linked Ubiquitination Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process Cellular Response To Nutrient Levels Nucleotide Binding Transferase Activity Macromolecule Metabolic Process Death Effector Domain Binding Protein K11-linked Ubiquitination Regulation Of TOR Signaling Protein Catabolic Process Ripoptosome CD95 Death-inducing Signaling Complex Protein Monoubiquitination Negative Regulation Of Intracellular Signal Transduction Response To Nutrient Levels Negative Regulation Of Signal Transduction Positive Regulation Of Protein Polyubiquitination Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Execution Phase Of Apoptosis Execution Phase Of Apoptosis Protein K6-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Protein Polyubiquitination Protein-containing Complex DNA Damage Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?