CASP7 and HSPA5

Number of citations of the paper that reports this interaction (PubMedID 11943137)
37

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CASP7	HSPA5
Description		caspase 7	heat shock protein family A (Hsp70) member 5
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Regulation Of Transcription By RNA Polymerase II Proteolysis Apoptotic Process Heart Development Response To UV Protein Processing Protein Catabolic Process Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Ceramide Biosynthetic Process Striated Muscle Cell Differentiation Neuron Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Lymphocyte Apoptotic Process Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis Positive Regulation Of Plasma Membrane Repair	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs		Fica Emricasan Incadronic acid	Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 22561518 27723757)	Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HNRNPH1 HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A TRIM25 UBE4B VIM XIAP	77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB
Entrez ID		840	3309
HPRD ID		03457	00682
Ensembl ID		ENSG00000165806	ENSG00000044574
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	P11021 V9HWB4
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z 7WZS 8DGZ 8DJ3	3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Cytosol Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleus Cytoplasm Intracellular Signal Transduction Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Cellular Component Organization Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Execution Phase Of Apoptosis Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cellular Response To Stress Myeloid Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Regulation Of Cell Communication Regulation Of Necroptotic Process Protein Metabolic Process Cysteine-type Endopeptidase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Protein Maturation Regulation Of Programmed Necrotic Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Protein Processing	Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding
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