CASP7 and RAD21

Number of citations of the paper that reports this interaction (PubMedID 11875078)
0

Data Source:
HPRD (in vitro)

		CASP7	RAD21
Description		caspase 7	RAD21 cohesin complex component
Image
GO Annotations	Cellular Component	Fibrillar Center Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Chromosome, Centromeric Region Chromatin Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Cohesin Complex Membrane Nuclear Matrix Midbody Mitotic Cohesin Complex Meiotic Cohesin Complex
	Molecular Function	RNA Binding Catalytic Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Regulation Of Transcription By RNA Polymerase II Proteolysis Apoptotic Process Heart Development Response To UV Protein Processing Protein Catabolic Process Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Ceramide Biosynthetic Process Striated Muscle Cell Differentiation Neuron Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Lymphocyte Apoptotic Process Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis Positive Regulation Of Plasma Membrane Repair	Response To Hypoxia DNA Repair Double-strand Break Repair DNA Recombination Regulation Of Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Chromosome Segregation Sister Chromatid Cohesion Reciprocal Meiotic Recombination Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Establishment Of Mitotic Sister Chromatid Cohesion Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Sister Chromatid Cohesion Cell Division Protein Localization To Chromatin Chromatin Looping Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs		Fica Emricasan Incadronic acid
Diseases
GWAS		Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 22561518 27723757)	Menopause (age at onset) ( 29773799)
Interacting Genes		63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HNRNPH1 HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A TRIM25 UBE4B VIM XIAP	30 interacting genes: CAPN1 CASP7 CFL1 CSTB DISC1 DYNLT1 FHL3 FLNB HNRNPH2 IL7R MSRB2 MT-CO2 NUMA1 PPP1R15A PPP1R15B PTEN RPL10 RPL13 RPL35A SMARCA5 SMC1A SSU72 STAG1 STAG2 SUMO2 TMSB4X TNFRSF14 WAPL WNT2B ZNF80
Entrez ID		840	5885
HPRD ID		03457	05924
Ensembl ID		ENSG00000165806	ENSG00000164754
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	O60216
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z 7WZS 8DGZ 8DJ3	4PJU 4PJW 4PK7 6QNX 6RRC 6RRK 6WG3 6WGE 7W1M 7ZJS 8K4D 8P0A 8PQ5 8RO6 8RO7 8RO8 8RO9 8ROA 8ROB 8ROC 8ROD 8ROE 8ROF 8ROG 8ROH 8ROI 8ROJ 8ROK 8ROL
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Cytosol Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleus Cytoplasm Intracellular Signal Transduction Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Cellular Component Organization Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Execution Phase Of Apoptosis Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cellular Response To Stress Myeloid Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Regulation Of Cell Communication Regulation Of Necroptotic Process Protein Metabolic Process Cysteine-type Endopeptidase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Protein Maturation Regulation Of Programmed Necrotic Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Protein Processing	Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Establishment Of Sister Chromatid Cohesion Mitotic Spindle Pole Spindle Assembly Microtubule Cytoskeleton Organization Nuclear Matrix Microtubule Cytoskeleton Organization Involved In Mitosis Cytoskeleton Organization Chromosome Segregation Spindle Organization Cytosol Microtubule-based Process Sister Chromatid Cohesion Mitotic Spindle Assembly Negative Regulation Of Cell Size Membraneless Organelle Assembly Cell Division Establishment Of Spindle Localization Cytosolic Large Ribosomal Subunit RNA Binding Spindle Localization Chromosome, Centromeric Region Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Cell Size Positive Regulation Of Proteolysis Actin Binding Regulation Of Proteolysis Mitotic Spindle Organization Cytosolic Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ficolin-1-rich Granule Lumen Cofilin-actin Rod Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Regulation Of Cellular Component Size Positive Regulation Of Barbed-end Actin Filament Capping Regulation Of Cell-matrix Adhesion Positive Regulation Of Protein Localization To Cell Leading Edge Cortical Microtubule Meiotic Cell Cycle Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Chromosome Organelle Assembly
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