Wiki-Pi
About
Search
People
Updates
Search
CASP7 and PTGES3
Number of citations of the paper that reports this interaction (PubMedID
22451931
)
37
Data Source:
BioGRID
(enzymatic study, enzymatic study)
CASP7
PTGES3
Description
caspase 7
prostaglandin E synthase 3
Image
GO Annotations
Cellular Component
Fibrillar Center
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Telomerase Holoenzyme Complex
Cytoplasm
Cytosol
Protein-containing Complex
Protein Folding Chaperone Complex
Molecular Function
RNA Binding
Catalytic Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Telomerase Activity
Protein Binding
Isomerase Activity
Prostaglandin-E Synthase Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
Hsp90 Protein Binding
DNA Polymerase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Plasma Membrane Repair
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Apoptotic Process
Heart Development
Response To UV
Protein Processing
Protein Catabolic Process
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Ceramide Biosynthetic Process
Striated Muscle Cell Differentiation
Neuron Apoptotic Process
Protein Maturation
Protein Poly-ADP-ribosylation
Lymphocyte Apoptotic Process
Pyroptotic Inflammatory Response
Cellular Response To Lipopolysaccharide
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Positive Regulation Of Plasma Membrane Repair
Telomere Maintenance
Prostaglandin Biosynthetic Process
Protein Folding
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Prostaglandin Metabolic Process
Telomere Maintenance Via Telomerase
Signal Transduction
Positive Regulation Of Telomere Maintenance Via Telomerase
Prostanoid Biosynthetic Process
Protein Stabilization
Chaperone-mediated Protein Complex Assembly
Telomerase Holoenzyme Complex Assembly
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
HSF1 activation
Attenuation phase
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression
Potential therapeutics for SARS
Drugs
Fica
Emricasan
Incadronic acid
Acetaminophen
Grn163l
Copper
Diseases
GWAS
Cataracts (
34127677
)
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
22561518
27723757
)
Alanine aminotransferase levels (
33547301
)
Asthma (
31619474
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Mean platelet volume (
22139419
)
Platelet count (
22139419
)
Reticulocyte count (
32888494
)
Interacting Genes
63 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HNRNPH1
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
TRIM25
UBE4B
VIM
XIAP
30 interacting genes:
AHR
AHSA1
AIP
ARNT
CASP3
CASP7
CAV3
CD2AP
CDC37
COPG1
COPG2
DNAJB1
DNMT3A
EIF2AK2
ERBB3
ESR1
FES
GZMB
HSF1
HSP90AA1
HSPA1A
HSPB1
MAPT
NR3C1
NR3C2
SIM2
STIP1
SURF1
TERT
THRA
Entrez ID
840
10728
HPRD ID
03457
06138
Ensembl ID
ENSG00000165806
ENSG00000110958
Uniprot IDs
A0A0A0MRL7
B4DWA2
P55210
A0A087WYT3
B3KUY2
Q15185
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
7WZS
8DGZ
8DJ3
1EJF
7KRJ
7L7I
7L7J
Enriched GO Terms of Interacting Partners
?
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Cytosol
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Nucleus
Cytoplasm
Intracellular Signal Transduction
Enzyme Binding
Regulation Of Primary Metabolic Process
Negative Regulation Of Cellular Component Organization
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Execution Phase Of Apoptosis
Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Neuron Apoptotic Process
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
Cellular Response To Stress
Myeloid Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Protein-containing Complex Assembly
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Necroptotic Process
Protein Metabolic Process
Cysteine-type Endopeptidase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteolysis
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Communication
Protein Maturation
Regulation Of Programmed Necrotic Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Protein Processing
Hsp90 Protein Binding
Nuclear Receptor Activity
TBP-class Protein Binding
Unfolded Protein Binding
Response To Temperature Stimulus
Response To Heat
Regulation Of Gene Expression
Cellular Response To Heat
Regulation Of Macromolecule Biosynthetic Process
Response To Lipid
Protein Folding Chaperone
Regulation Of Macromolecule Metabolic Process
Aryl Hydrocarbon Receptor Complex
Regulation Of Apoptotic Process
Protein Folding Chaperone Complex
Cytoplasm
Positive Regulation Of Microtubule Polymerization
Positive Regulation Of Protein Polymerization
Response To Unfolded Protein
Regulation Of Programmed Cell Death
Regulation Of Primary Metabolic Process
Intracellular Signal Transduction
Regulation Of Metabolic Process
Cytosol
Response To Stress
Regulation Of Protein-containing Complex Assembly
Estrogen Response Element Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Lipid
Protein-folding Chaperone Binding
Negative Regulation Of Inclusion Body Assembly
Protein Folding
Negative Regulation Of Biosynthetic Process
Animal Organ Development
Regulation Of Cellular Response To Heat
Intracellular Receptor Signaling Pathway
Nuclear Aryl Hydrocarbon Receptor Complex
Neurofibrillary Tangle Assembly
Protein-containing Complex
Regulation Of Neuron Apoptotic Process
Regulation Of Microtubule Polymerization
Regulation Of Inclusion Body Assembly
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Multicellular Organismal Process
Response To Hormone
Positive Regulation Of Metabolic Process
Response To Hypoxia
Sequence-specific DNA Binding
Cellular Response To Oxygen-containing Compound
DNA-binding Transcription Factor Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?