CASP7 and GORASP1

Number of citations of the paper that reports this interaction (PMID 11815631)
47

Data Source:
HPRD (in vivo, in vitro)

		CASP7	GORASP1
Gene Name		caspase 7, apoptosis-related cysteine peptidase	golgi reassembly stacking protein 1, 65kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Golgi Apparatus
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis	Mitotic Cell Cycle Golgi Organization Protein Transport Negative Regulation Of Dendrite Morphogenesis
Pathways		Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins Apoptotic factor-mediated response SMAC binds to IAPs Apoptotic execution phase Programmed Cell Death SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Intrinsic Pathway for Apoptosis	Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Cell Cycle, Mitotic M Phase
Drugs		Fica
Diseases
GWAS		Vitiligo ( 22561518)
Protein-Protein Interactions		60 interactors: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	14 interactors: AGPS CASP3 CASP7 CDK1 GOLGA2 HIPK3 LONRF1 MAPK6 PLK1 PRKD2 SCRN1 TGFA TMED2 TMED3
Entrez ID		840	64689
HPRD ID		03457	06038
Ensembl ID		ENSG00000165806	ENSG00000114745
Uniprot IDs		B4DWA2 P55210	B3KPY8 B4E1H8 Q9BQQ3
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Response To Stress Response To Stimulus Regulation Of Cellular Component Organization Cell Communication Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Signaling Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Intracellular Signal Transduction Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Signaling Myeloid Cell Differentiation System Development Regulation Of Metabolic Process Cellular Response To Organic Substance Viral Process Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Peptidase Activity Anatomical Structure Development Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Multicellular Organismal Development Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process	Peptidyl-serine Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Proteolysis Protein Localization To Chromosome Positive Regulation Of Catalytic Activity Regulation Of Cell Death Negative Regulation Of Cell Death G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Cell Death Death Negative Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Nuclear Division Nuclear Envelope Disassembly Negative Regulation Of Kinase Activity Peptidyl-threonine Phosphorylation Regulation Of MAPK Cascade Regulation Of Proteolysis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of MAP Kinase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Pronuclear Fusion Positive Regulation Of Protein Phosphorylation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Transferase Activity Protein Phosphorylation Nuclear Envelope Organization Negative Regulation Of Protein Phosphorylation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Execution Phase Of Apoptosis
Tagcloud ?		balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds	adc aldh1l1 ankrd28 bhlhe40 cggbp1 ctdspl ephb1 fbln2 fgd5 foxp1 gnai2 iqsec1 itga itga9 loc285205 loc285375 lrrc3b lrrn1 mitf nkiras1 noti rbsp3 rpl15 rpl32 thrb ttc21 ube2e2 vhl wnt7a
Tagcloud (Difference) ?		balb casp3 casp8 caspase3 closure d10 d5 d7 dermal execution extrinsic fasr harvested healing innovation intersect intrinsic mechanistically mucosal preprogrammed punch scarring therapeutics tnfrsf1b tongue tradd trp53 wound wounds	adc aldh1l1 ankrd28 bhlhe40 cggbp1 ctdspl ephb1 fbln2 fgd5 foxp1 gnai2 iqsec1 itga itga9 loc285205 loc285375 lrrc3b lrrn1 mitf nkiras1 noti rbsp3 rpl15 rpl32 thrb ttc21 ube2e2 vhl wnt7a
Tagcloud (Intersection) ?