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CASP7 and DFFA
Number of citations of the paper that reports this interaction (PubMedID
10318789
)
0
Data Source:
HPRD
(in vitro)
CASP7
DFFA
Description
caspase 7
DNA fragmentation factor subunit alpha
Image
GO Annotations
Cellular Component
Fibrillar Center
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Protein-containing Complex
Molecular Function
RNA Binding
Catalytic Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Protein Binding
Protein Domain Specific Binding
Protein Folding Chaperone
Deoxyribonuclease Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Plasma Membrane Repair
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Apoptotic Process
Heart Development
Response To UV
Protein Processing
Protein Catabolic Process
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Ceramide Biosynthetic Process
Striated Muscle Cell Differentiation
Neuron Apoptotic Process
Protein Maturation
Protein Poly-ADP-ribosylation
Lymphocyte Apoptotic Process
Pyroptotic Inflammatory Response
Cellular Response To Lipopolysaccharide
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Positive Regulation Of Plasma Membrane Repair
Apoptotic DNA Fragmentation
Protein Folding
Apoptotic Process
Negative Regulation Of Deoxyribonuclease Activity
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Thymocyte Apoptotic Process
Negative Regulation Of Execution Phase Of Apoptosis
Negative Regulation Of Apoptotic DNA Fragmentation
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Apoptosis induced DNA fragmentation
Drugs
Fica
Emricasan
Incadronic acid
Diseases
GWAS
Cataracts (
34127677
)
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
22561518
27723757
)
Depression in smokers (
30219690
)
Male-pattern baldness (
28196072
29146897
)
Interacting Genes
63 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HNRNPH1
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
TRIM25
UBE4B
VIM
XIAP
12 interacting genes:
AGO2
CASP3
CASP7
CIDEB
DFFB
EWSR1
GZMB
GZMM
NECAB2
STRN4
YWHAG
YWHAZ
Entrez ID
840
1676
HPRD ID
03457
03531
Ensembl ID
ENSG00000165806
ENSG00000160049
Uniprot IDs
A0A0A0MRL7
B4DWA2
P55210
O00273
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
7WZS
8DGZ
8DJ3
1IBX
1IYR
1KOY
Enriched GO Terms of Interacting Partners
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Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Cytosol
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Nucleus
Cytoplasm
Intracellular Signal Transduction
Enzyme Binding
Regulation Of Primary Metabolic Process
Negative Regulation Of Cellular Component Organization
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Execution Phase Of Apoptosis
Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Neuron Apoptotic Process
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
Cellular Response To Stress
Myeloid Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Protein-containing Complex Assembly
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Necroptotic Process
Protein Metabolic Process
Cysteine-type Endopeptidase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteolysis
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Communication
Protein Maturation
Regulation Of Programmed Necrotic Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Protein Processing
Execution Phase Of Apoptosis
Cellular Response To Staurosporine
Pyroptotic Inflammatory Response
Cell Death
Apoptotic Process
Programmed Cell Death
Protein Domain Specific Binding
Fibroblast Apoptotic Process
Protein Maturation
Protein Poly-ADP-ribosylation
Positive Regulation Of Immune Response To Tumor Cell
Regulation Of Amyloid Precursor Protein Biosynthetic Process
Aspartic-type Endopeptidase Activity
Regulation Of Primary Metabolic Process
Regulation Of Synapse Maturation
Peptidase Activity
Plasma Membrane Repair
Regulation Of Response To Tumor Cell
Negative Regulation Of Translation
Cellular Response To Alkaloid
Regulation Of Glycoprotein Biosynthetic Process
Hydrolase Activity
Cytoplasm
Protein Sequestering Activity
Leukocyte Apoptotic Process
Neuron Recognition
Glutamatergic Synapse
Negative Regulation Of Translational Initiation
Postsynapse
Cellular Response To Glucose Starvation
Negative Regulation Of Macromolecule Metabolic Process
Ceramide Biosynthetic Process
Identical Protein Binding
Endoribonuclease Activity, Cleaving SiRNA-paired MRNA
Regulation Of Metabolic Process
Proteolysis
Cysteine-type Endopeptidase Activity
TORC1 Signaling
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Synapse Organization
Striated Muscle Cell Differentiation
Response To External Biotic Stimulus
Phospholipase A2 Activator Activity
Cytolytic Granule Lumen
Leukocyte Mediated Cytotoxicity
Synaptic Target Recognition
Endoribonuclease Activity, Cleaving MiRNA-paired MRNA
Negative Regulation Of G Protein-coupled Receptor Internalization
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