ASCC2 and PIK3CD

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASCC2	PIK3CD
Description		activating signal cointegrator 1 complex subunit 2	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex	Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Transferase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Natural Killer Cell Differentiation Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Leukocyte Mediated Immunity Mast Cell Chemotaxis Respiratory Burst Involved In Defense Response Protein Phosphorylation Lipid Metabolic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression T Cell Chemotaxis Cell Migration Regulation Of Anatomical Structure Morphogenesis Natural Killer Cell Activation Cell Differentiation B Cell Differentiation T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Neutrophil Apoptotic Process Natural Killer Cell Chemotaxis B Cell Chemotaxis Phosphatidylinositol-3-phosphate Biosynthetic Process Vascular Endothelial Growth Factor Signaling Pathway T Cell Activation B Cell Activation Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Innate Immune Response Positive Regulation Of Angiogenesis Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Mast Cell Differentiation Neutrophil Extravasation Positive Regulation Of Epithelial Tube Formation Regulation Of Multicellular Organismal Development
Pathways		ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer CD28 dependent PI3K/Akt signaling Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by CSF1 (M-CSF) in myeloid cells Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs			Caffeine XL765 TG100-115 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE Idelalisib Duvelisib Fostamatinib Copanlisib Umbralisib
Diseases
GWAS		Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Spleen volume ( 34128465) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)	Diisocyanate-induced asthma ( 25918132) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Irritable bowel syndrome ( 29626450) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Systemising ( 31508503) Testicular germ cell tumor ( 28604728)
Interacting Genes		41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1	15 interacting genes: ASCC2 ERAS HRAS IL3 IL4 IRS2 KITLG MCRIP2 PIK3CG PIK3R1 PIK3R2 RALY SNCA TAGLN TNPO2
Entrez ID		84164	5293
HPRD ID		16515	04161
Ensembl ID		ENSG00000100325	ENSG00000171608
Uniprot IDs		Q9H1I8	A0A2K8FKV1 A0A8V8TM62 A7E2E0 B7ZM44 O00329
PDB IDs		2DI0 6YXQ	5DXU 5M6U 5T8F 5UBT 5VLR 6G6W 6OCO 6OCU 6PYR 6PYU 7JIS 7LM2 7LQ1 8BCY 8S3R 9GCF 9GDI
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Nucleoplasm	Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Complex, Class IA Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Locomotion Cellular Response To Insulin Stimulus Regulation Of Myeloid Leukocyte Differentiation Intracellular Signaling Cassette Regulation Of Generation Of Precursor Metabolites And Energy T Cell Activation Leukocyte Activation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Small Molecule Metabolic Process Immune System Process Regulation Of Protein Localization To Cell Periphery 1-phosphatidylinositol-3-kinase Regulator Activity Regulation Of Cell Migration Response To Insulin Regulation Of Apoptotic Process Cell Activation Phosphatidylinositol 3-kinase Activator Activity Regulation Of Cell Motility Cellular Response To Peptide Hormone Stimulus Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Epithelial Cell Migration Regulation Of Osteoclast Differentiation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Myeloid Cell Differentiation Lymphocyte Activation Immune Response Ras Protein Signal Transduction Regulation Of Cell Adhesion Intracellular Glucose Homeostasis Protein Phosphatase Binding Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Protein Localization Phosphatidylinositol 3-kinase Binding Response To Peptide Hormone B Cell Differentiation Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Phosphate Metabolic Process Cell Surface Receptor Signaling Pathway
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