ASCC2 and ASS1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ASCC2	ASS1
Name		activating signal cointegrator 1 complex subunit 2	argininosuccinate synthase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuronal Cell Body Perikaryon Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Ligase Activity Identical Protein Binding
	Biological Process	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development L-arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Response To Nutrient Circadian Rhythm Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Mycotoxin Response To Amine Response To Estradiol Response To Lipopolysaccharide Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Steroid Hormone Response To Glucocorticoid Response To Growth Hormone Diaphragm Development Response To Fatty Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Urea cycle
Drugs		None	Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP
Diseases		None	Citrullinemia (CTLN)
GWAS		Bipolar disorder or attention deficit hyperactivity disorder ( 27890468 ) Crohn's disease ( 28067908 ) Hemoglobin levels ( 32327693 ) IgA levels ( 28628107 ) Immature fraction of reticulocytes ( 27863252 ) Inflammatory bowel disease ( 28067908 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Refractive error ( 32231278 ) Spleen volume ( 34128465 ) Telomere length ( 24478790 ) Tonsillectomy ( 27941131 ) Type 2 diabetes ( 30297969 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )	Femur bone mineral density x serum urate levels interaction ( 34046847 )
Novel Interactors		None recorded	3 novel interactors: NUP214 PMPCA STOM
Interacting Genes		41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1	15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A PTPN1 SLC13A1 SUMO2 TERF1 TERF2 USP4
Entrez ID		84164	445
HPRD ID		16515	04590
Ensembl ID		ENSG00000100325	ENSG00000130707
Uniprot IDs		Q9H1I8	P00966 Q5T6L4
PDB IDs		2DI0 6YXQ	2NZ2
GO Terms Enriched among Interactors		Macromolecule Metabolic Process Nucleoplasm	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Endosome Lumen Negative Regulation Of Mitotic Recombination Cellular Response To Interleukin-3 Regulation Of Mitotic Recombination Telomerase Activity Shelterin Complex Signaling Receptor Activator Activity Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Acetylcholine Receptor Binding Postsynapse Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Intracellular Copper Ion Homeostasis Regulation Of Establishment Of Protein Localization Copper Ion Homeostasis Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Insulin Receptor Binding Cellular Response To Copper Ion Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Signaling Pathway RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ephrin Receptor Binding Telomeric DNA Binding Positive Regulation Of Macromolecule Metabolic Process Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Copper Ion Enzyme Binding Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Cell Activation Involved In Immune Response