ASCC2 and POLDIP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASCC2	POLDIP2
Description		activating signal cointegrator 1 complex subunit 2	DNA polymerase delta interacting protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex	Nucleus Mitochondrion Mitochondrial Matrix Cell-cell Junction Midbody Mitochondrial Nucleoid Mitotic Spindle
	Molecular Function	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	DNA Binding Protein Binding
	Biological Process	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	DNA Repair DNA Damage Response Mitochondrion Organization Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Focal Adhesion Assembly Error-free Translesion Synthesis Mitotic Spindle Assembly Positive Regulation Of Mitotic Cytokinesis Vascular Associated Smooth Muscle Cell Proliferation
Pathways		ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Spleen volume ( 34128465) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)	Osteoprotegerin levels ( 25080503)
Interacting Genes		41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1	19 interacting genes: AGTRAP ALAS1 APP ASCC2 CPE DNAAF6 DSCAM FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1
Entrez ID		84164	26073
HPRD ID		16515	17874
Ensembl ID		ENSG00000100325	ENSG00000004142
Uniprot IDs		Q9H1I8	B4DEM9 Q9Y2S7
PDB IDs		2DI0 6YXQ	6Z9C 6ZLX
Enriched GO Terms of Interacting Partners?		Macromolecule Metabolic Process Nucleoplasm	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process Error-prone Translesion Synthesis DNA Replication Zeta DNA Polymerase Complex Neuron Projection Organization DNA Repair Response To Stress Regulation Of Growth DNA Strand Elongation Involved In DNA Replication DNA Metabolic Process Regulation Of Axon Extension Involved In Axon Guidance Collateral Sprouting Neuron Projection Morphogenesis DNA Strand Elongation DNA Damage Response Cellular Response To Stress Dendritic Spine Morphogenesis Ubiquitin Binding Cell Projection Morphogenesis DNA-directed DNA Polymerase Activity Positive Regulation Of Mitophagy Regulation Of Developmental Growth Positive Regulation Of Autophagy Of Mitochondrion Macromolecule Metabolic Process Central Nervous System Development Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Regulation Of Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Dendritic Spine Organization Macromolecule Biosynthetic Process Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cell Projection Organization Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Locomotion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Growth PCNA Complex Replisome Response To Dexamethasone 3-phosphoinositide-dependent Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Clustering
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