BCAR3 and KPNA1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BCAR3	KPNA1
Gene Name		breast cancer anti-estrogen resistance 3	karyopherin alpha 1 (importin alpha 5)
Image
Gene Ontology Annotations	Cellular Component		Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Dendrite
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Nuclear Localization Sequence Binding Protein Transporter Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of GTPase Activity	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Intracellular Transport Of Virus
Pathways			Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism HIV Infection Host Interactions of HIV factors Interferon Signaling Apoptotic execution phase Integration of provirus Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Early Phase of HIV Life Cycle Influenza Life Cycle HIV Life Cycle Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		6 interactors: APP ERBB2 ERBB3 KPNA1 NEDD9 RPRD1A	32 interactors: ANP32A ANP32B BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 FOSL1 GOPC HDAC6 HIST2H2BE HIST3H3 IL1RAP KPNB1 LEF1 LMO4 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 RAG1 RANBP2 RUNX1T1 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5
Entrez ID		8412	3836
HPRD ID		05268	02819
Ensembl ID		ENSG00000137936	ENSG00000114030
Uniprot IDs		B3KNL6 B3KP06 O75815	B3KXZ2 P52294
PDB IDs		3T6A	2JDQ 3TJ3 4B18
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Signaling Neuromuscular Junction Development Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Neuron Death Cell Surface Receptor Signaling Pathway Peripheral Nervous System Development Wound Healing Regulation Of Growth Response To Wounding Synaptic Growth At Neuromuscular Junction Phosphatidylinositol-mediated Signaling Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Innate Immune Response Synapse Organization Glial Cell Differentiation Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Dephosphorylation Of RNA Polymerase II C-terminal Domain Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Gliogenesis Cell Death Death Regulation Of Protein Phosphorylation Axon Choice Point Recognition Positive Regulation Of Cellular Protein Metabolic Process Fc Receptor Signaling Pathway Regulation Of Translation Regulation Of Nitrogen Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Differentiation In Thymus Neuron Remodeling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase III Promoter Signal Transduction	Response To Cytokine Cellular Response To Cytokine Stimulus Nucleocytoplasmic Transport Nuclear Transport Cytokine-mediated Signaling Pathway Mitotic Nuclear Envelope Disassembly Cytoplasmic Transport Nuclear Envelope Disassembly Viral Process Nucleobase-containing Compound Metabolic Process Nucleus Organization RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Nitrogen Compound Metabolic Process Nuclear Envelope Organization Mitotic Cell Cycle Process Intracellular Transport Cellular Nitrogen Compound Metabolic Process Glucose Transport Regulation Of Cell Death Hexose Transport Regulation Of Cellular Protein Metabolic Process Macromolecule Biosynthetic Process Mitotic Cell Cycle Viral Life Cycle Viral Transcription Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Transport Response To Organic Substance Regulation Of Glucose Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Establishment Of Protein Localization Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance MRNA Transport Regulation Of Proteolysis Carbohydrate Transport RNA Metabolic Process Apoptotic Process Establishment Of Localization In Cell RNA Transport
Tagcloud ?		adjuvant bcl2 cohorts dutch easily endpoint esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney	acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream
Tagcloud (Difference) ?		adjuvant bcl2 cohorts dutch easily endpoint esr1 favorable implemented indicative mann menopausal naive nat1 ncoa1 pfs pgr predictive promise qpcr select setting signatures start stratify tamoxifen transcriptase univariate whitney	acids arginine auto best binds cdc34 conjugating karyopherin ligase localization lysine manipulation participates possesses promoted putative rad6 rag1 rearrangement recombinase rich spanning supported ubch2 ubch5a ubiquitin ubiquitylation undergo upstream
Tagcloud (Intersection) ?