BCAR3 and BEX1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BCAR3	BEX1
Description		BCAR3 adaptor protein, NSP family member	brain expressed X-linked 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Membrane Anchoring Junction	Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	Transcription Coactivator Binding Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Endothelin Receptor Signaling Pathway	Signal Transduction Nervous System Development Cell Differentiation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 DRC4 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45	31 interacting genes: AKT1 BAG4 BCAR3 CASP8 CHEK2 CNOT2 CTAG1A CTAG1B CYSRT1 FBXW7 FGFR2 FZR1 GSK3B KLHL20 KRT31 KRT34 MAGEA2 MAGEA2B MDFI MEOX2 NGFR OMP OTP PAX2 PICK1 PIK3CA PTEN PTPN11 SMAD4 TENM1 TEX11
Entrez ID		8412	55859
HPRD ID		05268	06460
Ensembl ID		ENSG00000137936	ENSG00000133169
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	Q9HBH7
PDB IDs		3T6A
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Tyrosine Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Response To Epidermal Growth Factor Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Epithelial Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Molecular Function Inhibitor Activity Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Protein Modification Process Protein Kinase Activity Positive Regulation Of Lymphocyte Migration Positive Chemotaxis ERBB2-EGFR Signaling Pathway Growth Factor Binding Regulation Of Primary Metabolic Process Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway	Cellular Developmental Process Developmental Process Ubiquitin Protein Ligase Binding Positive Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Proteolysis Carbohydrate Homeostasis Positive Regulation Of Catalytic Activity Glucose Homeostasis Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination PML Body Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Programmed Cell Death Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Intracellular Glucose Homeostasis Negative Regulation Of Protein Acetylation Animal Organ Development
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