BCAR3 and VPS45

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BCAR3	VPS45
Description		BCAR3 adaptor protein, NSP family member	vacuolar protein sorting 45 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Membrane Anchoring Junction	Golgi Membrane Endosome Golgi Apparatus Synaptic Vesicle Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding	Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Endothelin Receptor Signaling Pathway	Intracellular Protein Transport Protein Transport Vesicle-mediated Transport
Pathways			Intra-Golgi traffic SARS-CoV-2 modulates autophagy Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hip circumference adjusted for BMI ( 34021172) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)
Interacting Genes		38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 DRC4 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45	13 interacting genes: BCAR3 CASP8 IGF1R PAX2 PTPN1 RB1CC1 RBSN SNCA SNTG1 STX16 USP25 VPS11 VPS18
Entrez ID		8412	11311
HPRD ID		05268	10301
Ensembl ID		ENSG00000137936	ENSG00000136631
Uniprot IDs		A0A384MTS3 B3KNL6 B3KP06 O75815	A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7
PDB IDs		3T6A
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity ERBB2 Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Protein Tyrosine Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial Cell Proliferation Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Epithelial Cell Proliferation ERBB3:ERBB2 Complex Response To Epidermal Growth Factor Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Epithelial Cell Proliferation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Molecular Function Inhibitor Activity Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Regulation Of Protein Modification Process Protein Kinase Activity Positive Regulation Of Lymphocyte Migration Positive Chemotaxis ERBB2-EGFR Signaling Pathway Growth Factor Binding Regulation Of Primary Metabolic Process Cell Population Proliferation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Signaling Pathway Via STAT ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Basolateral Plasma Membrane Positive Regulation Of Cell Migration Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway	Regulation Of SNARE Complex Assembly Vesicle-mediated Transport Syntaxin Binding CORVET Complex Vacuole Organization Vesicle Docking Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Organelle Localization By Membrane Tethering Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway HOPS Complex Membrane Docking Endosomal Vesicle Fusion Synaptic Vesicle Priming Vesicle Fusion Organelle Membrane Fusion Negative Regulation Of Programmed Cell Death Insulin Receptor Binding Lysosomal Transport Early Endosome Organelle Fusion Synaptic Vesicle Synaptic Vesicle Membrane Regulation Of JNK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Membrane Fusion Negative Regulation Of Intracellular Signal Transduction Regulation Of Cytokine-mediated Signaling Pathway Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Response To Fibroblast Growth Factor Trans-Golgi Network To Recycling Endosome Transport Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribophagy Vesicle Docking Involved In Exocytosis Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Vacuolar Transport Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Organelle Localization Negative Regulation Of Response To Endoplasmic Reticulum Stress Lysosome Regulation Of Signal Transduction Cellular Response To Glucose Stimulus
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