PRAM1 and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRAM1	TP53BP2
Description		PML-RARA regulated adaptor molecule 1	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding Protein Homodimerization Activity NF-kappaB Binding
	Biological Process	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Apoptotic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Coronary artery disease ( 29212778) Height ( 18391951)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		26 interacting genes: A2M ABI2 APOE APP BCAR1 CCDC57 CDC37 CEBPA FXR1 FXR2 GOLGA2 KRT40 LCP2 LYN MAST1 MXD1 NEDD9 NEK6 PSEN1 RNF32 SH3RF1 SKAP1 SKAP2 TP53BP2 TRIM27 UBE2E2	119 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP INSYN2A IQUB KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBC UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		84106	7159
HPRD ID		05926	11803
Ensembl ID		ENSG00000133246	ENSG00000143514
Uniprot IDs		Q96QH2	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation SH3 Domain Binding Regulation Of Dendritic Spine Maintenance Regulation Of Immune System Process Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Lipoprotein Particle Regulation Of Amyloid Fibril Formation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Regulation Of Immune Response Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Proteolysis Regulation Of Synaptic Plasticity Astrocyte Activation Involved In Immune Response Positive Regulation Of Protein Catabolic Process Intermediate-density Lipoprotein Particle Positive Regulation Of Dendritic Spine Maintenance Growth Factor Receptor Binding T Cell Receptor Signaling Pathway Memory Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Long-term Synaptic Potentiation Cytoplasm Learning Or Memory Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Amyloid-beta Signaling Receptor Activator Activity Regulation Of Amyloid Precursor Protein Catabolic Process Cytoskeleton Organization Regulation Of Synapse Organization Cytosol Supramolecular Fiber Organization Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Immune System Process Cognition Positive Regulation Of Phosphate Metabolic Process Response To Amyloid-beta Neuron Projection Positive Regulation Of Metabolic Process Regulation Of Defense Response Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Neuron Projection Maintenance	Protein Binding Cytosol Cytoplasm Regulation Of Protein Metabolic Process Nucleus Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Kinase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Postsynaptic Cytosol Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Radiation Cytoskeleton Regulation Of Protein Modification Process Centrosome Negative Regulation Of Signaling Negative Regulation Of Cell Communication Nucleoplasm Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of JNK Cascade Plasma Membrane Bounded Cell Projection Organization Identical Protein Binding PTW/PP1 Phosphatase Complex Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Cell Projection Organization Regulation Of Primary Metabolic Process Protein Domain Specific Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Channel Inhibitor Activity NF-kappaB P50/p65 Complex Regulation Of Neurogenesis Regulation Of Post-translational Protein Modification Regulation Of Protein Catabolic Process Protein Metabolic Process Regulation Of Gene Expression
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