PRAM1 and SKAP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PRAM1	SKAP1
Gene Name		PML-RARA regulated adaptor molecule 1	src kinase associated phosphoprotein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Plasma Membrane Cell-cell Junction
	Molecular Function	Protein Binding Lipid Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding SH2 Domain Binding
	Biological Process		Positive Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter T Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Height ( 18391951)	Epilepsy (generalized) ( 22949513) Ovarian cancer ( 20852632)
Protein-Protein Interactions		19 interactors: A2M ABI2 APOE APP CCDC57 CDC37 FXR2 KRT40 LCP2 LYN MAST1 MXD1 NEK6 PSEN1 RNF32 SKAP1 SKAP2 TRIM27 UBE2E2	12 interactors: APP BLCAP FAM102A FYB FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		84106	8631
HPRD ID		05926	05396
Ensembl ID		ENSG00000133246	ENSG00000141293
Uniprot IDs		Q96QH2	Q86WV1
PDB IDs			1U5D
Enriched GO Terms of Interacting Partners?		Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cytokine Secretion Establishment Of Localization In Cell Antigen Receptor-mediated Signaling Pathway Secretion Regulation Of Protein Metabolic Process Cell Activation Regulation Of Protein Kinase Activity Cellular Localization Negative Regulation Of Catalytic Activity Platelet Activation Regulation Of Kinase Activity Signal Transduction Negative Regulation Of Protein Kinase Activity Regulation Of Immune System Process Cellular Response To Stimulus Platelet Degranulation Negative Regulation Of Kinase Activity Regulation Of Cellular Process Regulation Of Signal Transduction Signaling Neuron Development Negative Regulation Of Cellular Metabolic Process Cell Communication Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation T Cell Receptor Signaling Pathway Regulation Of Signaling Regulation Of Proteolysis Neuron Differentiation Exocytosis Response To Wounding Protein Secretion Negative Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Cytokine Production Negative Regulation Of Phosphorylation Response To Stress Cellular Component Assembly Protein Localization Regulation Of Phosphorylation Regulation Of Cellular Component Organization Protein Metabolic Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Blood Coagulation Hemostasis Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Immune System Process Leukocyte Migration Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Fc Receptor Signaling Pathway Wound Healing Chemotaxis Regulation Of Cell Adhesion Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Locomotion Response To Wounding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Innate Immune Response Neuron Projection Development Cell Migration Cell Projection Morphogenesis Regulation Of Phosphorus Metabolic Process
Tagcloud ?		2b4 acgh annotation c3h cd244 cnv congolense crosses damaging hej hybridisation infect lies livestock mbp plausible protozoan qtl resequencing sickness sleeping snp synonymous tir1 tir2 tir3 tir3c trypanosoma trypanosomes	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		2b4 acgh annotation c3h cd244 cnv congolense crosses damaging hej hybridisation infect lies livestock mbp plausible protozoan qtl resequencing sickness sleeping snp synonymous tir1 tir2 tir3 tir3c trypanosoma trypanosomes	10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?